PT -期刊文章盟Pietro美极AU -弗朗西斯科Zellini AU -亚历山德罗Barilaro盟-亚历山德罗Passeri盟卢卡Massacesi TI -时间的多发性硬化病变MRI可视化:洞察焦病理学(P3.015) DP - 2016年4月05 TA -神经病学PG - P3.015 VI - 86 IP - 16补充4099 - //www.ez-admanager.com/content/86/16_Supplement/P3.015.short 4100 - http://n.neurology首页.org/content/86/16_Supplement/P3.015.full所以Neurology2016 4月05;86 AB -背景:核磁共振成像提供了体内见解焦女士病理学上不同的序列不同的底层生物现象很敏感。目的:分析新女士病变体积变化随着时间的推移,使用不同的核磁共振技术和提出一个MS病灶形成的模型。方法:患者RR (n = 12)随访女士每月在1.5 T MRI扫描仪。(Gd)钆增强病变的体积(n = 100, 16圈和84结节)是评估在天赋和T1w单一(T1wGdSD)和三(T1wGdTD)剂量的Gd。我们称为“峰值”体积,最高的一个记录在每月跟进“天赋的结果”卷结束后6个月T1w增强。动时间进程分析应用于天赋和T1wGd卷和病理生理动机两个随机行走动力学数学模型应用到天赋卷。结果:在急性期,天赋体积在高峰导致祝辞T1wGdTD是祝辞T1wGdSD卷在高峰,显示类似的钟形的概要文件。天赋的结果数量总是& lt;T1wGd卷在高峰。 The FLAIR volume resulted to be described by two random walks curves: a rapid onset one, with similar shape compared to the T1wGd curve and a second one beginning at the same time but slowly increasing and decreasing. Both nodular (R2 0.7 ±0.1) and ring (R2 0.81 ±0.08) lesions were described by this model with high fitting quality. CONCLUSIONS: In the acute phase the pathologic substrate of the lesions is made of overlapping layers: a central “core”, containing inflammation, blood brain barrier (BBB) disruption and irreversible tissue damage and an external “penumbra”, with reversible BBB and tissue damage surrounded by water diffusing from the inner layers. This biological model was valid for both nodular and ring enhancing lesions suggesting a similar physiopathological substrate.Disclosure: Dr. Maggi has nothing to disclose. Dr. Zellini has nothing to disclose. Dr. Barilaro has nothing to disclose. Dr. Passeri has nothing to disclose. Dr. Massacesi has nothing to disclose.Monday, April 18 2016, 8:30 am-7:00 pm