RT期刊文章SR电子T1磁共振皮层下和皮层灰质在肌萎缩性脊髓侧索硬化症(P4.096)摩根富林明神经病学神经学乔FD Lippincott Williams &威尔金斯SP P4.096 VO 86是16补充A1 Eugenio Distaso A1 Domenico Mezzapesa A1 E首页ustachio D 'Errico A1安东尼奥Scarafino A1亚历山德罗Introna A1罗莎Cortese A1艾琳Tempesta A1 Francesco费德里科•A1语言Dicuonzo A1伊莎贝拉西蒙年2016 UL //www.ez-admanager.com/content/86/16_Supplement/P4.096.abstract AB目的:本研究的目的是为了执行一个体积和先生的形态学分析ALS患者的皮层下灰质(SGM)和搜索相关性SGM措施先生和皮质厚度(车车)的电动机和extramotor区域。背景:肌萎缩性脊髓侧索硬化症(ALS)的特点是extramotor参与广泛证明了病理和非传统的神经影像学研究。实际上一些研究发现SGM参与ALS使用morphovolumetric先生的分析。方法:35零星的古典的诊断ALS患者(平均年龄58.51岁,标准差11.03;男性17),25名健康受试者(HS)(平均年龄55.66岁,标准差11.46;男性13)已经被包括在内。3 d-t1加权图像先生被1.5吨通用电气收购扫描仪。第一个(目前的一个工具)是用于SGM分割和执行形状分析,Freesurfer软件被用来评估大脑车车。结果:形状分析显示小集群区域的变化分析皮层下结构,更相关的丘脑外侧核和壳(背侧核),与健康对照组相比。ALS患者之间没有显著差异和控制的体积的皮层下结构被发现。ALS患者的海马、杏仁核和伏隔核与车车的运动皮层呈正相关,额叶和岛叶(p = 0.001未修正的; whereas volumes of caudate and putamen negatively correlated with CTh of motor areas and frontal cortex (p=0.001 uncorrected). Conclusions: We found mild structural changes of SGM in ALS patients, more relevant in term of shape than of volume, particularly in regions of thalamus and putamen with motor cortex connection. This corroborates the hypothesis of a network degeneration in ALS. However the ambivalent correlation between the volume of SGM nuclei and CTh suggests that neurodegeneration is not uniform in the different networks.Disclosure: Dr. Distaso has nothing to disclose. Dr. Mezzapesa has nothing to disclose. Dr. D'Errico has nothing to disclose. Dr. Scarafino has nothing to disclose. Dr. Introna has nothing to disclose. Dr. Cortese has nothing to disclose. Dr. Tempesta has nothing to disclose. Dr. Federico has nothing to disclose. Dr. Dicuonzo has nothing to disclose. Dr. Simone has received personal compensation for activities with Sanofi Aventis and Biogen.Tuesday, April 19 2016, 8:30 am-7:00 pm