TY -的T1神经突方向色散和密度成像(NODDI)对微观结构损伤敏感相关残疾Relapse-Onset女士(S41.003) JF -神经学乔-神经学六世- 86 - 16补充SP - S41.003 AU -华莱士Brownlee AU -帕特里夏·阿尔维斯·莫塔AU -弗兰普拉多盟-施奈德托本盟- m·乔治·卡多佐Sebastien首页 Ourselin AU -丹尼尔•阿尔特曼盟盟克劳迪娅甘迪尼Wheeler-Kingshott AU -奥尔加Ciccarelli盟David Miller Y1 - 2016/04/05 UR - //www.ez-admanager.com/content/86/16_Supplement/S41.003.abstract N2 -目的:应用神经突方向色散和密度成像(NODDI) Relapse-Onset多发性硬化(MS)患者和调查NODDI指标之间的关系和临床残疾。背景:扩散磁共振成像大脑微观结构损伤敏感女士包括髓鞘脱失和neuroaxonal损失。NODDI是一种新型扩散磁共振成像技术,提供更具体的信息在大脑组织微观结构比标准扩散张量成像,但尚未被应用之前患者群体的方法:女士78 MS患者(64年复发缓和女士(名RRMS)和14个二级进步(spm)女士,意味着疾病持续时间14.7年,所有跟随预期从独联体出现)和36名健康对照组3 t diffusion-weighted成像和常规MRI扫描。NODDI配件和大脑分割获得三个指标:执行方向色散指数(ODI),神经突密度指数(NDI)和各向同性的体积分数(isoVF)灰质(GM)和正常白质(NAWM)。残疾评估患者使用扩展残疾状态量表(eds)、定时25英尺走测试(行)和9洞桩测试(9 pt)。线性回归是用来比较NODDI指标组间的差异。多变量线性回归是用来识别独立NODDI指标之间的关联和残疾,调整年龄、性别、疾病持续时间和大脑实质分数。结果:患者降低NAWM-NDI女士(术中;0.001)和更高的NAWM-ODI(术中,0.001),GM-isoVF(术中,0.001)和NAWM-isoVF比控制(p = 0.029)。spm病人GM-ODI较高(p = 0.011)和低NAWM-NDI比名RRMS患者(p = 0.035)。在回归模型NAWM-NDI和GM-ODI独立与eds (R²= 0.38),和NAWM-NDI TWT (R²= 0.24)和9 pt (R²= 0.33)。 CONCLUSIONS: NODDI is sensitive to tissue damage in relapse-onset MS. The association of lower NAWM-NDI with disability and SPMS suggests this metric reflects pathological changes in NAWM that contribute to long-term disability and disease progression.Disclosure: Dr. Brownlee has nothing to disclose. Dr. Alves Da Mota has nothing to disclose. Dr. Prados has nothing to disclose. Dr. Schneider has nothing to disclose. Dr. Cardoso has nothing to disclose. Dr. Altmann has nothing to disclose. Dr. Ourselin has nothing to disclose. Dr. Gandini Wheeler-Kingshott has nothing to disclose. Dr. Ciccarelli has received personal compensation for activities with Novartis, Biogen and GE as a consultant. Dr. Miller has nothing to disclose.Wednesday, April 20 2016, 1:00 pm-3:00 pm ER -