% 0期刊文章% Adeolu Morawo %一个玛格丽特Pisani Shahrin佩雷拉% %哈尔Blumenfeld %劳伦斯·赫希%艾米丽·吉尔摩凯文Sheth % % T理解大脑失败在脓毒症的病理生理学使用脑电图和NIRS (P1.312) % D J神经病学2016% % P P1.312 X % V % 86% N 16补充目的:本研究的目的是获取勘探信息推进以下假设:无创连续脑电图和NIRS签名与脓毒症患者大脑失败。首页背景:弥漫性脑功能障碍是一种常见的,通常败血症的早期特征;它的存在与贫穷相关功能和神经认知的结果。脑灌注不足和损失适应性反应的大脑血管脑代谢需求的增加可能参与脓毒症相关的大脑失败(SABF)。方法:患者败血症,严重脓毒症和脓毒性休克承认医学ICU是48 - 72小时使用注册和监控技术有或没有临床表示连续的脑电图。这些数据是寿命与平均动脉压、心率、呼吸率和使用多通道监测动脉血氧饱和度。精神状态评估使用gc,四个分数和CAM-ICU。疾病的严重程度评估使用沙发和APACHE II。结果:十多种感染性疾病患者(败血症(N = 2),严重脓毒症(N = 1)和脓毒性休克(N = 7)),平均年龄为59.7岁已经登记。6 (60 [percnt])患者精神状态改变(AMS)引起败血症而4 (40 [percnt])患者完整的感觉器官。 SABF was defined as GCS 3-13 and/or positive CAM-ICU within the first 24 hours of admission. Cursory analysis reveals lower cerebral oximetry in patients with SABF when compared to septic patients without SABF. Conclusions: This study is in its early stages of enrollment. Though there is a trend towards lower cerebral oximetry in patients with SABF, these findings must be confirmed as more patients are enrolled and correlated with other surrogates of cerebral and systemic perfusion. Study Supported By: CTSA Grant Number KL2 TR000140Disclosure: Dr. Morawo has nothing to disclose. Dr. Pereira has nothing to disclose. Dr. Pisani has nothing to disclose. Dr. Blumenfeld has nothing to disclose. Dr. Hirsch has received personal compensation for activities with Lundbeck, Upsher-Smith, Neuropace, Marinus, GlaxoSmithKline, Eisai, Sunovion and UCB-Pharma as consultant and Neuropace as speaker. Dr. Hirsch has received research support from Yale for in Dr. Sheth has nothing to disclose. Dr. Gilmore has nothing to disclose.Saturday, April 16 2016, 8:30 am-7:00 pm %U