TY - T1的行为变异额颞叶退化或帕金森病?不是所有的性欲亢进是冲动控制障碍(P6.387) JF -神经学乔-神经学六世- 86 - 16补充SP - P6.387盟记者年首页轻盟——凯瑟琳·盟丹尼尔Claassen Y1 - 2016/04/05 UR - //www.ez-admanager.com/content/86/16_Supplement/P6.387.abstract N2 -目的:描述一系列案例4患者性欲亢进对减少多巴胺治疗。背景:多巴胺失调综合症和冲动控制障碍(ICD)是很不适应的行为综合症与多巴胺治疗。我们提出一系列患者性欲亢进和被诊断出患有行为变异额颞叶退化(bvFTD)作为这些症状的原因。设计/方法:我们进行了一个回顾医疗记录,神经影像学、神经心理学测试,和四个疗程病人对于ICD的帕金森病(PD),但重新归类为bvFTD-PD重叠。结果:所有患者在这种情况下系列呈现给范德比尔特大学神经病学临床伴有震颤麻痹和性欲亢进的症状和诊断PD-ICD。首页详细的历史显示,行为变化之前暴露于左旋多巴治疗3例,并开始后2 - 3年稳定在1例左旋多巴治疗。非常好色的症状包括婚外情、妓女征集和色情小进步。减少左旋多巴并没有解决性欲过度的症状。神经心理测试在3例强调重要的执行功能障碍(困难小径,转移,特鲁干扰,和词检索),符合额颞叶退化模式的认知功能障碍。 18F-flurodeoxyglucose PET scans in 3 patients revealed differing degrees of frontal-temporal hypometabolism. All patients met clinical criteria for a diagnosis of behavioral variant FTD. Management of these patients included SSRIs (n=4), medroxyprogesterone (n=2), and clozapine (n=1). Symptoms improved in all cases with medical management. CONCLUSIONS: This case series emphasizes that not all ‘ICD behaviors’ in PD are attributable to dopamine therapy. In some cases, these symptoms may instead represent an FTD overlap syndrome, a relationship well-described in previous genetic studies of FTDP-17. Symptomatic treatment for these cases ranged from SSRI use to atypical antipsychotics and hormone therapy, but overall symptoms were effectively managed over time.Disclosure: Dr. Young has nothing to disclose. Dr. McDonell has nothing to disclose. Dr. Claassen has received research support from Auspex Pharmaceuticals.Thursday, April 21 2016, 8:30 am-5:30 pm ER -