文摘
摘要目的:描述COVID-19大流行(即经验。,testing, infections, hospitalizations, patient characteristics) in participants of the population-based Mayo Clinic Study of Aging.
背景:老年人的风险较高,更糟糕的结果后COVID-19感染,特别是那些并发症,包括认知障碍
设计/方法:4429年一群MCSA参与者,我们从2020年3月至2022年9月检索COVID-19测试使用罗彻斯特流行病学项目资源。此外,我们评估了“严重的感染,”定义为住院治疗后7天前3个月内积极的测试。所有参与者进行一个全面的认知评价MCSA在每个访问。卡方测试和t与平等的方差是用来比较两个样品组
结果:3399例(76.7%)受试者对COVID-19感染检测,和956年(平均年龄(SD)首先积极测试:71.3(15.5)年;51.3%的男性)阳性。参与者进行测试(永远比没有测试)平均年龄的增长,高体重指数(BMI)、高Charlson发病率指数(CCI),更有可能被淘汰。参与者阳性(vs -)平均年轻,不太可能有认知障碍或退休,CCI较低。参与者与严重感染(N = 212 (22.2%);而不是“严重”)平均明显长大,更可能有认知障碍,更高的CCI,提高民族地区剥夺指数排名,更少的年的教育,更有可能被淘汰
结论:MCSA参与者阳性更有可能更年轻,更没有认知能力受损而严重感染可能是老和认知能力受损。我们发现增加积累的知识以人群为基础的研究表明年龄和认知障碍的重要性COVID-19严重感染,消除偏见。调查结果突显出有价值的信息考虑在未来的大流行性流感预防干预措施
披露:Ghoniem博士没有披露。耶利米Aakre没有披露。安娜·卡斯蒂略没有披露。Elminawy博士没有披露。Machulda博士的机构收到NIH的研究支持。Geda博士的机构收到NIH的研究支持。Vemuri博士已经收到个人薪酬在500 - 4999美元的范围为在演讲人米勒医疗服务通信公司. .Vemuri博士的机构收到NIH的研究支持。杰克收到博士研究的机构国家卫生研究院的支持。杰克收到博士研究的机构支持亚历山大家族阿尔茨海默病研究教授梅奥诊所。 Dr. Graff-Radford has received personal compensation for serving as an employee of Mayo Clinic. Dr. Graff-Radford has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for NINDS/NIH. Dr. Graff-Radford has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Academy of Neurology. The institution of Dr. Graff-Radford has received research support from NIH. Dr. Knopman has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for DIAN TU study. The institution of Dr. Knopman has received research support from NIH. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Nestle. Dr. Petersen has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech, Inc.. Dr. Petersen has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche, Inc.. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has received publishing royalties from a publication relating to health care. The institution of Dr. Vassilaki has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for F. Hoffmann-La Roche Ltd . Dr. Vassilaki has stock in Abbott Laboratories. Dr. Vassilaki has stock in Johnson and Johnson. Dr. Vassilaki has stock in Medtronic. Dr. Vassilaki has stock in Amgen. Dr. Vassilaki has stock in AbbVie. Dr. Vassilaki has stock in Merck. The institution of Dr. Vassilaki has received research support from NIH. The institution of Dr. Vassilaki has received research support from European Union/ St. Anne’s University Hospital Brno, Czech Republic. The institution of an immediate family member of Dr. Vassilaki has received research support from Avobis Bio, LLC.
