文摘
摘要目的:确定每个丘脑核和疲劳和探索之间的联系是否有氧能力的影响在这个症状是由多发性硬化症患者的丘脑(pwm)。
背景:疲劳是一种常见的症状在pwm影响生理和心理域。不同的因素包括有氧能力,残疾和认知障碍导致疲劳的感觉。丘脑,核相关运动和认知方面,参与疲劳发病机理。
设计/方法:74年这个横断面分析,pwm进行了临床评估与评级规模扩大残疾状态(eds),修改后的疲劳影响规模(小额信贷机构)和符号数字形式测试(SDMT);心肺运动试验评估最大摄氧量(VO2max)和脑MRI量化全球和丘脑核卷。一群47 sex-and-age-matched健康对照组(HC)包括核磁共振数据的比较,而HC(10)的小组也提出VO2max值。
结果:在pwm,疲劳与萎缩的左lateral-dorsal丘脑核(热阻:−0.278,p≤0.018),人的认知,而不是身体上的疲劳。严重疲劳(更高的小额信贷机构)降低的最大摄氧量(热阻:−0.263,p = 0.027),更高的eds(热阻:0.353,p = 0.003)和低SDMT(热阻:−0.353,p = 0.003)。后两个有关在丘脑萎缩的普遍模式。较低的最大摄氧量只有lateral-dorsal丘脑核的萎缩有关。在HC,较高的有氧能力与更大体积的丘脑,枕和腹侧核(热阻:从0.674到0.714,p≤0.012)。在pwm,有一个重要的间接影响的有氧能力通过左边的体积在疲劳lateral-dorsal丘脑核(b =−0.305,可信区间[−0.678−0.005])。
结论:有氧能力产生积极影响疲劳有关这效果是由左女士lateral-dorsal丘脑核。
披露:Albergoni博士没有披露。Morozumi先生没有披露。伊丽莎白帕加尼没有披露。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在百时美施贵宝公司的演讲人。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在赛诺菲Genzyme的演讲人。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在诺华的演讲人。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在罗氏的演讲人。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在默克的演讲人。莫妮卡Margoni接到MAGNIMS研究支持。菲利皮主持博士已经收到个人薪酬在5000 - 9999美元的范围作为顾问拜耳、Idec, Merck-Serono,诺华,罗氏公司,赛诺菲安万特Genzyme,武田和梯瓦制药产业。 Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, Teva Pharmaceutical Industries, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, and ARiSLA (Fondazione Italiana di Ricerca per la SLA). Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Bristol Myers Squibb, Celgene, Genzyme, Merck Serono, Novartis, Roche, and Teva. The institution of Maria Assunta Rocca has received research support from Italian Ministry of Health, MS Society of Canada and Fondazione Italiana Sclerosi Multipla.
