文摘
摘要目的:识别认知表型小儿多发性硬化症(MS)使用一种无监督的机器学习方法。
背景:最近的研究发现不同的认知表型在成人MS患者使用非监督机器学习方法。
设计/方法:53儿科医学患者进行临床检查包括扩大残疾状态量表(eds)来评估全球残疾。全面的神经心理学电池(选择性提醒测试、空间记忆测试,跟踪测试,符号位模式测试,语义语言流畅测试和音位的口头表达测试)是所有病人管理。每个测试的原始分数是根据规范数据转换为z得分。认知测试z分数被包含在k - means聚类分析来识别认知表型。人口群体间的比较,临床和认知变量计算使用线性回归模型或非参数测试。统计学意义是纠正为多个比较(Bonferroni方法)。
结果:在我们的样例,平均年龄为15.9岁(四分位范围(差)13.6 - 16.8)、68%(36例)女孩和疾病持续时间的平均值为1.8±1.7年。聚类分析确定三个认知表型:保存认知(27例[51%]),轻微的非文字记忆/语义流畅性参与(19例[36%])和严重的多畴的参与(7例[13%])。跨组织,没有明显差异在年龄、性别和疾病持续时间。eds的得分越低被发现保存患者的认知(eds中位数1.0[差1.0 - 1.0])比轻度患者非文字记忆/语义流畅性参与(eds中值1.5(差1.0 - 2.0);p = 0.01)和患者严重的多畴的参与(eds中位数2.0(差1.25 - 2.75);p = 0.004)。
结论:儿科患者存在明显的认知表型女士从保存认知到严重的多畴的参与。认知表型并不与年龄、性别和疾病持续时间。保存患者认知的特点是低全球残疾。
披露:达米斯特里没有披露。莫妮卡Margoni接到MAGNIMS研究支持。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在百时美施贵宝公司的演讲人。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在赛诺菲Genzyme的演讲人。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在诺华的演讲人。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在罗氏的演讲人。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在默克的演讲人。亚历山德罗代表我没有披露。卡门Vizzino没有披露。Moiola博士没有披露。 Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, Teva Pharmaceutical Industries, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, and ARiSLA (Fondazione Italiana di Ricerca per la SLA). Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Bristol Myers Squibb, Celgene, Genzyme, Merck Serono, Novartis, Roche, and Teva. The institution of Maria Assunta Rocca has received research support from Italian Ministry of Health, MS Society of Canada and Fondazione Italiana Sclerosi Multipla.
