文摘
摘要目的:我们检查了神经心理学的主要进步(PP)和次要进步(SP)多发性硬化(MS)患者和调查认知功能之间的关系结构和功能磁共振成像异常。
背景:研究比较频率和模式认知功能障碍的项目组合管理系统与spm之间产生了相互矛盾的结果。
设计/方法:一百八十三MS患者(60项目组合管理系统和123 spm)和75岁,sex-matched健康对照组接受3.0 t磁共振成像。MS患者进行神经心理测试的短暂的可重复的电池(BRB-N),分为认知损害如果他们的得分低于5th百分位的规范样本至少两个测试。四个认知域z分数从规范数据测定,然后平均获得全球认知的测量(z-BRB-N)。利用分层线性回归分析,损伤的贡献量,规范化的脑容量,白质部分各向异性(FA)和平均扩散系数(MD)异常,和静止状态(RS)功能连通性(FC)改变全球认知项目组合管理系统和spm调查。
结果:项目组合管理系统和spm患者有相似的z分数在所有调查认知领域。项目组合管理系统相比,spm中FA减少,增加了MD穹窿,并降低基底神经节内RS FC网络。认知障碍的频率在spm在项目组合管理系统是31.7%,41.3% (p = 0.19)。在项目组合管理系统,贫穷的认知能力(如低z-BRB-N)与FA的内侧丘系(ΔR下降2= 0.11;p = 0.011)和较低的规范化灰质体积(ΔR2= 0.29;p < 0.001)。在spm,贫穷的认知能力与FA穹窿(ΔR下降有关2= 0.35;p < 0.001),降低规范化白质体积(ΔR2= 0.05;p = 0.034)。
结论:项目组合管理系统和spm有类似的神经心理档案。认知功能障碍相关的项目组合管理系统和spm截然不同的模式结构的MRI异常和参与不同的白质束,而RS FC改变不有助于解释他们的全球认知功能。
披露:达米斯特里没有披露。Cacciaguerra女士已经收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或数据安全监测委员会罗氏。Cacciaguerra女士已经收到个人薪酬在500 - 4999美元的范围在演讲人BMS Celgene公司服务。Cacciaguerra女士已经收到个人薪酬在500 - 4999美元的范围在赛诺菲的演讲人。Cacciaguerra女士已经收到个人薪酬在500 - 4999美元的范围服务扬声器BIOMEDIA管理局。Paola Valsasina已收到个人薪酬在500 - 4999美元的范围服务扬声器ACCMED管理局。伊丽莎白帕加尼没有披露。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在百时美施贵宝公司的演讲人。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在赛诺菲Genzyme的演讲人。Preziosa先生已经收到个人薪酬在500 - 4999美元的范围在诺华的演讲人。 Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck. Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Bristol Myers Squibb, Celgene, Genzyme, Merck Serono, Novartis, Roche, and Teva. The institution of Maria Assunta Rocca has received research support from Italian Ministry of Health, MS Society of Canada and Fondazione Italiana Sclerosi Multipla. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, Teva Pharmaceutical Industries, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, and ARiSLA (Fondazione Italiana di Ricerca per la SLA).
