文摘
摘要目的:开发机器学习(ML)模型预测全球认知和注意力下降从神经影像学生物标志物的阿尔茨海默病(AD)和神经精神症状(NPS)。
背景:毫升越来越多地用于大脑衰老的研究。
设计/方法:我们开发了4毫升模型(支持向量机,高斯过程,随机森林,朴素贝叶斯)来预测全球认知和关注域z分数变化之间的第一个和最后一个研究每个参与者的访问。我们使用了一个分段的方法开发的预测模型:1)包括广告生物标志物(加以- &正),教育,和APOEɛ4状态;其次是2)增加抑郁的措施(贝克抑郁Inventory-II;BDI-II),和焦虑(贝克焦虑量表;白);然后3)添加12个NPS包括NPS严重程度以神经精神量表问卷(NPI-Q)。
结果:数据从777年认知没有(铜)参与者的结果全球认知z分数,和795立方参与者注意z分数的结果是可用的。80%的样本是随机用来训练模型,盲目测试剩下的20%。为全球认知,最好的模型能够预测78%的参与者减少z分数使用广告生物标志物,教育,和APOEɛ4状态。添加BDI-II和白预测提高到87%;并添加12 NPS进一步提高预测和减少z得分96%的参与者。包括NPS严重性并未提高模型的性能。关注的领域,最好的模型预测89%的参与者减少z分数使用广告生物标志物,教育,和APOEɛ4状态。添加BDI-II和白测量之后,该模型能够预测与z分数的减少97%的参与者。添加12 NPS和NPI严重性略微提高了模型的性能达到98%。
结论:毫升有可能成功预测全球和特定领域的认知能力下降在社区的人,NPS改善预测相比,AD神经影像生物标志物。
披露:沙先生没有披露。杰里米Syrjanen没有披露。Krell-Roesch博士没有披露。沃尔特·克雷默的机构收到生原体的研究支持。Vemuri博士已经收到个人薪酬在500 - 4999美元的范围为在演讲人米勒医疗服务通信公司. .Vemuri博士的机构收到NIH的研究支持。Vassilaki博士的机构已收到个人薪酬在5000 - 9999美元的范围作为f .罗氏公司的顾问有限公司Vassilaki博士在雅培公司股票。Vassilaki博士在强生股票。Vassilaki博士在美敦力公司股票。 Dr. Vassilaki has stock in Amgen. Dr. Vassilaki has stock in AbbVie. Dr. Vassilaki has stock in Merck. The institution of Dr. Vassilaki has received research support from NIH. The institution of Dr. Vassilaki has received research support from European Union/ St. Anne’s University Hospital Brno, Czech Republic. The institution of an immediate family member of Dr. Vassilaki has received research support from Avobis Bio, LLC. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Genentech. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Nestle. Dr. Petersen has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech, Inc.. Dr. Petersen has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche, Inc.. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has received publishing royalties from a publication relating to health care. The institution of Dr. Forzani has received research support from NIH. The institution of Dr. Forzani has received research support from NSF. Dr. Forzani has received intellectual property interests from a discovery or technology relating to health care. Dr. Forzani has received personal compensation in the range of $100,000-$499,999 for serving as a Professor with Arizona State University. Dr. Wu has nothing to disclose. The institution of Dr. Geda has received research support from NIH.
