文摘
摘要目的:报告有睡眠指标的变化在复发多发性硬化(MS)患者接受了6个月生酮饮食(KD)干预。
背景:饮食摄入量影响免疫概要文件和响应。女士的饮食是有临床意义的影响,有证据支持一个饮食和残疾之间的联系。我们的之前的数据支持修改阿特金斯的耐受性和潜在的临床效益生酮饮食(KD疯了)患者的复发患者睡眠障碍是常见的女士和女士经常瘫痪,从而改善睡眠干预将是高度有效的。KDs癫痫与睡眠质量的改善,但是MS患者的影响仍然未知。
设计/方法:45成人患者复发女士被录取进6个KD疯了干预。通过日常监控饮食依从性尿酮测试。白天嗜睡评价(pre-diet)和饮食治疗6个月后埃普沃思嗜睡量表(ESS)和睡眠障碍症状Checklist-25 (SDS-CL-25)。ESS验证评估平均睡眠倾向的标记无序的睡眠。SDS-CL-25是几个睡眠障碍筛查工具,包括失眠和阻塞性睡眠呼吸暂停(OSA)。
结果:39 45受试者完成了全部6个月KD干预——包括预处理和post-diet ESS评估,而36个学科完成的两个SDS-CL-25评估。有一个意味着减少ESS评分从基线到6个月1.90±3.0 (p < 0.001)。日间极度嗜睡的相对频率(ESS评分> 10)在6个月减少饮食(15.4% vs 7.7%;p = 0.001)。有减少SDS-CL-25总分(−3.6±7.7;p = 0.008),意思是失眠的分数(−1.5±3.5;p = 0.013),意思是阻塞性睡眠呼吸暂停综合症的分数(−0.8±0.36;p = 0.014)。
结论:KD的疯了干预会导致改善患者白天嗜睡和睡眠障碍症状复发。
披露:帕尔曼博士没有披露。戴安娜Lehner-Gulotta没有披露。艾玛*使用368242惠特玛没有披露。科尔曼女士没有披露。Banwell博士已经收到个人薪酬在5000 - 9999美元的范围为诺华公司担任顾问。Banwell博士已经收到个人补偿的范围0 - 499美元为UCB担任顾问。Banwell博士已经收到个人薪酬在10000 - 49999美元的范围为罗氏公司担任顾问。Banwell博士已经收到个人薪酬在500 - 4999美元的范围作为顾问詹森。Banwell博士已经收到个人薪酬在10000 - 49999美元的范围为基因泰克公司担任顾问。Banwell博士已经收到个人补偿的范围0 - 499美元为科学顾问或服务数据安全监测委员会诺华。 The institution of Dr. Banwell has received research support from National MS Society. The institution of Dr. Banwell has received research support from NIH. Dr. Bergqvist has nothing to disclose. Dr. Chen has nothing to disclose. Mark Conaway has nothing to disclose. Dr. Goldman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for EMD Seronon. Dr. Goldman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen, IDEC. Dr. Goldman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Genzyme. Dr. Goldman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Genentec. Dr. Goldman has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for ADAMAS. Dr. Goldman has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Immunic. Dr. Goldman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis Pharmceuticals. Dr. Goldman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Greenwich Biosciences. Dr. Goldman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merk. Dr. Goldman has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Brainstorm Cell Therapeutics Ltd., . The institution of Dr. Morse has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Jazz Pharmaceuticals, Harmony Biosciences, Avadel Pharmaceuticals, Takeda Pharmaceuticals, Alkermes, National Institute for Health, and Geisinger Health Plan. The institution of Dr. Morse has received research support from Harmony Biosciences, Avadel Pharmaceuticals, Takeda Pharmaceuticals, Alkermes, National Institute for Health, and Geisinger Health Plan. Dr. Brenton has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Cycle Pharmaceuticals. The institution of Dr. Brenton has received research support from NIH/NINDS. Dr. Brenton has received personal compensation in the range of $500-$4,999 for serving as a Grant Reviewer with Department of Defense. Dr. Brenton has received personal compensation in the range of $500-$4,999 for serving as a Expert Interview with MDEdge. Dr. Brenton has received personal compensation in the range of $0-$499 for serving as a Grant Reviewer with NIH.
