文摘
摘要目的:评价外源性褪黑素在改善睡眠质量的功效在亨廷顿病(HD)基因携带者。
背景:在高清各种睡眠障碍已确定。褪黑激素水平低可能解释扰乱生理行为高清[1]。有证据表明睡眠质量改善测量的匹兹堡睡眠质量指数(PSQI)个人接收褪黑激素[2]。这是第一个研究评估在高清褪黑素的功效。
设计/方法:随机,双盲,安慰剂对照,交叉,概念验证研究。高清基因携带者与PSQI≥5和稳定的药物在过去的2个月从UTHealth招募,休斯顿HDSA卓越中心。高清睡眠问卷,PSQI埃普沃思嗜睡量表(ESS)、医院焦虑和抑郁量表(已经),临床全球印象(CGI)规模,UHDRSc接种。Wilcoxon符号秩检验是用来分析数据。
结果:我们招收15例(平均年龄47.5岁,46%的女性),73%的白人,13%的非裔美国人,13%是西班牙人。正如所料,褪黑素和安慰剂组显示显著差异PSQI-6以来他们服药的睡眠。有趣的是,相对于基线褪黑素组显著提高分数的高清睡眠问卷,并增加分数提高组件的CGI。没有指出了或ESS的差异。
结论:这个试点研究高清基因携带者演示了褪黑激素对睡眠障碍的潜在好处。符合之前的数据在其他神经退行性疾病,褪黑激素可以正面影响睡眠质量。其他变量包括体重指数的变化,分析UHDRS的子组件,和即将的生活质量的措施。未来的研究,使用客观评估polysomnogram或活动检测仪等,更大的样本量,并区分疾病阶段可能提供有价值的信息关于褪黑激素在高清的效用。
披露:博士Patino Murillas没有披露。Zadegan博士没有披露。萨姆纳塔莉亚•罗查没有披露。立即家人Karagas博士已收到个人作为补偿的员工三十麦迪逊。立即家人Karagas博士已收到个人薪酬在100000 - 499999美元的范围作为一个军官或董事会成员三十麦迪逊。立即家人Karagas博士30麦迪逊的股票。谷垣祯一没有披露。邓肯太太没有披露。Furr-Stimming博士已经收到个人薪酬在500 - 4999美元的范围为梯瓦制药担任顾问。Furr-Stimming博士已经收到个人薪酬在500 - 4999美元的范围作为顾问迈克尔·j·福克斯基金会。 Dr. Furr-Stimming has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Teva Pharmaceuticals. The institution of Dr. Furr-Stimming has received research support from Cures within Reach. The institution of Dr. Furr-Stimming has received research support from Huntington’s Disease Society of America. The institution of Dr. Furr-Stimming has received research support from Roche/Genetech. The institution of Dr. Furr-Stimming has received research support from Uniqure. The institution of Dr. Furr-Stimming has received research support from CHDI. The institution of Dr. Furr-Stimming has received research support from Huntington Study Group/Neurocrine. The institution of Dr. Furr-Stimming has received research support from NIH/University of Iowa. The institution of Dr. Furr-Stimming has received research support from Sage Therapeutics. Dr. Furr-Stimming has received publishing royalties from a publication relating to health care.
