文摘
摘要目的:我们试图确定最优分割点署的初步报告,与30天死亡率更高。
背景:缺血性中风是5th主要的死亡原因在美国。作为衡量中风的严重程度、初始署已被用于预测临床结果。
设计/方法:2005年、2010年和2015年所有住院,第一次急性缺血性中风事件发生在大辛辛那提5-county地区被确定。潜在的情况下接受图抽象和医生裁定,包括转让回顾署得分基于临床发现最初的陈述。描述性统计署估计研究年人口统计和医学历史。关于死亡率数据从国家获得死亡指数。Contal和O 'Quigley方法基于修改后的生存率较统计署的用于确定分割点得分与30天死亡率有关,和风险比率得到从Cox模型与调整性别、种族和年龄。
结果:2005年,2010年和2015年有1704,1818,1852缺血性中风事件,分别。术后死亡率分别为10.5%、9.6%、9.0%,分别。署的最佳分割点< 9,9到16和> 16被确定。在所有3期,3431名(84.5%)的情况下署主,352名(8.7%)9 - 16署,274年(6.8%)> 16。卡普兰Meier生存曲线3署组织图中所示。署> 16岁首次演讲与15倍(人力资源有95% CI: 13、19)增加30天的死亡风险比那些署< 9。
结论:国立卫生研究院的中风尺度分数预测死亡率,更高的署分数有更高的死亡风险。减少点报告识别子组中风的患者显著不同的预测。未来的研究应该评估如果超额死亡率风险严重中风后持续更广泛血栓切除术超过2015的实现。
披露:斯坦顿博士没有披露。罗宾逊博士的机构收到NIH的研究支持。罗宾逊博士的机构收到加州大学的研究支持。马修·j·里夫斯博士BVSc已收到个人薪酬在500 - 4999美元的范围作为一个编辑,副主编,或为美国心脏协会编辑顾问委员会成员。丁博士没有披露。简科没有披露。玛丽Haverbusch的机构已经接到研究所R01NS030678研究支持。凯萨琳Alwell没有披露。Opeolu Adeoye已收到个人薪酬在5000 - 9999美元的范围为在科学咨询服务或数据安全监测委员会尼科公司Opeolu Adeoye股票在诊断。制度的Opeolu Adeoye收到NIH /研究所的研究支持。 Dr. Coleman has nothing to disclose. Dr. De Los Rios La Rosa has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for AstraZeneca. Dr. Demel has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for MOSAIC. Dr. Demel has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Genentech. Dr. Ferioli has nothing to disclose. Dr. Flaherty has received personal compensation for serving as an employee of Sense Diagnostics, Inc. Dr. Flaherty has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Boeringher Engelheim. Dr. Flaherty has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for CSL Behring. Dr. Flaherty has received personal compensation in the range of $0-$499 for serving on a Speakers Bureau for Alexion. Dr. Flaherty has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for various law firms. Dr. Flaherty has stock in Sense Diagnostics, Inc. The institution of Dr. Flaherty has received research support from NINDS. Dr. Flaherty has received intellectual property interests from a discovery or technology relating to health care. Dr. Jasne has nothing to disclose. The institution of Dr. Khatri has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Lumosa. Dr. Khatri has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Bayer. The institution of Dr. Khatri has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Diamedica. Dr. Khatri has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Basking Biosciences. Dr. Khatri has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Heart Association. The institution of Dr. Khatri has received research support from Cerenovus. Dr. Khatri has received publishing royalties from a publication relating to health care. Dr. Mackey has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for legal firms. The institution of Dr. Mackey has received research support from PCORI. Dr. Martini has nothing to disclose. Eva Mistry has nothing to disclose. Dr. Slavin has nothing to disclose. Dr. Star has nothing to disclose. Dr. Woo has nothing to disclose. Kyle Walsh has nothing to disclose. The institution of Dr. Kissela has received research support from NIH/NINDS and NCATS. Dr. Kleindorfer has nothing to disclose.
