文摘
摘要目的:确定协会临床各种MRI措施和后续发展的女士在影像上孤立综合症患者(pwRIS)。
背景:我们之前发现大多数pwRIS有很高比例的白质病变阳性中央静脉(CVS + L)和至少一个顺rim病变(PRL),分别代表perivenular和慢性活跃的髓鞘脱失。PRL和CVS + L是否涉及到的风险开发临床女士pwRIS前瞻性是未知的。
设计/方法:PwRIS前瞻性和接受3 t-mri被吸收了,包括3 d-flair和T2 *分段EPI的大脑,和矢状T1-PSIR颈脊髓(SC)。核磁共振成像评估存在PRL上,CVS + L, SC病变(sci)。
结果:36 pwRIS(平均年龄43年,70%女性,平均时间的临床随访6.3年)被纳入研究。临床开发的女士9例(25%)受试者临床事件的平均时间为5.2年。发达名RRMS 67%和33%的项目组合管理系统。在基线,pwRIS谁开发临床女士对那些没有有较高的平均数量的PRL(11和1,p = 0.01)和CVS + L (34 vs 10, p = 0.04)。纵向,新大脑病变,PRL, CVS + L (p < 0.01)和sci (p = 0.02)高于那些女士随后开发临床多变量逻辑回归使用向后逐步选择确定基线PRL算作最预测变量的发展女士在基线和随访成像措施(p = 0.01)。
结论:女士在这个前瞻性群组pwRIS, 25%发达后5年内初步诊断,诊断为项目组合管理系统为33%。基线PRL计数是最预测MRI测量临床pwRIS女士,后续发展的建议是否可能预后效用。继续跟进这批确认和验证在较大的数据集将重要的临床预测价值在pwRIS PRL和CVS + L。
披露:哦收到博士个人薪酬在5000 - 9999美元的范围为罗氏公司担任顾问。博士的机构哦收到个人薪酬在5000 - 9999美元的范围为Biogen-Idec担任顾问。哦收到博士个人薪酬在500 - 4999美元的范围为百时美施贵宝担任顾问。哦收到博士个人薪酬在5000 - 9999美元的范围为EMD-Serono担任顾问。哦收到博士个人薪酬在5000 - 9999美元的范围为Sanofi-Genzyme担任顾问。哦收到博士个人薪酬在500 - 4999美元的范围为诺华公司担任顾问。哦收到博士个人薪酬在500 - 4999美元的范围为礼来公司担任顾问。博士哦收到个人补偿的范围0 - 499美元为在科学咨询服务或数据安全监测委员会罗氏。博士哦收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或数据安全监测委员会Biogen-Idec。博士哦收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或数据安全监测委员会Sanofi-Genzyme。 The institution of Dr. Oh has received research support from Biogen-Idec. The institution of Dr. Oh has received research support from EMD-Serono. The institution of Dr. Oh has received research support from Biogen-Idec. Timothy R. Lim has nothing to disclose. Dr. Suthiphosuwan has nothing to disclose. Dr. Espiritu has nothing to disclose. Melanie Guenette has nothing to disclose. Dr. Bharatha has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. The institution of Dr. Sati has received research support from National Multiple Sclerosis Society. The institution of Dr. Sati has received research support from National Institutes of Health. Dr. Sati has received publishing royalties from a publication relating to health care. Dr. Absinta has received personal compensation in the range of $500-$4,999 for serving as a Consultant for GSK. Dr. Absinta has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abata Therapeutics. The institution of Dr. Absinta has received research support from International MS Alliance. The institution of Dr. Absinta has received research support from FRRB Early Career Award. The institution of Dr. Absinta has received research support from Cariplo Foundation. Dr. Reich has received research support from NIH. The institution of Dr. Reich has received research support from Vertex Pharmaceuticals. The institution of Dr. Reich has received research support from Adelson Medical Research Foundation. The institution of Dr. Reich has received research support from Myelin Repair Foundation. The institution of Dr. Reich has received research support from Sanofi-Genzyme. The institution of Dr. Reich has received research support from Abata Therapeutics. The institution of Dr. Reich has received research support from National Multiple Sclerosis Society. Dr. Reich has received personal compensation in the range of $500-$4,999 for serving as a CME Faculty with PeerView. Dr. Reich has received personal compensation in the range of $500-$4,999 for serving as a CME Faculty with AcademicCME. Dr. Reich has a non-compensated relationship as a Advisor with Sanofi-Genzyme that is relevant to AAN interests or activities. Dr. Reich has a non-compensated relationship as a Board of Directors with ACTRIMS that is relevant to AAN interests or activities. Dr. Reich has a non-compensated relationship as a Advisor with Abata Therapeutics that is relevant to AAN interests or activities. Dr. Reich has a non-compensated relationship as a Advisor with Roche that is relevant to AAN interests or activities. Dr. Reich has a non-compensated relationship as a Advisor with American Brain Foundation that is relevant to AAN interests or activities. Dr. Reich has a non-compensated relationship as a Advisor with University of Basel RC2NB that is relevant to AAN interests or activities. Dr. Reich has a non-compensated relationship as a Advisor with Multiple Sclerosis Society of Canada that is relevant to AAN interests or activities. Dr. Reich has a non-compensated relationship as a Advisor with Tuscan Doctorate in Neuroscience that is relevant to AAN interests or activities. Dr. Reich has a non-compensated relationship as a Editorial Board with Multiple Sclerosis Journal that is relevant to AAN interests or activities. Dr. Reich has a non-compensated relationship as a Advisor with Glaxo-Smith-Kline that is relevant to AAN interests or activities.
