文摘
摘要目的:探讨结构性改变大脑网络的患者在额颞叶的变性(FTLD)频谱使用连接体分析先进diffusion-weighted MRI指标。
背景:核磁共振——是一个有前途的工具来描述基于网络的退化在神经退行性疾病。神经突方向色散和密度成像(NODDI)显示在结构连通性变化提供新的见解。
设计/方法:34 behavioral-variant额颞叶痴呆(bvFTD), 11个语义变体原发性进行性失语(svPPA), 11迟滞型(nfvPPA)患者和48名健康对照组接受multi-shell扩散磁共振成像。计算分数各向异性(FA)地图。胞内体积分数(ICVF)地图也使用NODDI估计,提供一个直接量化神经突的完整性。图分析和评估——全球和本地拓扑网络结构属性和地区结构连接。
结果:总的来说,普遍的结构性变化观察bvFTD患者相对于健康对照组和svPPA病人FA-derived网络属性。nfvPPA病人还显示改变FA拓扑性质在全球水平与健康对照组相比。节点权重的总和(SN)感觉运动叶透露,nfvPPA病人比svPPA显示连接强度的改变。此外,nfvPPA病人表现出显著降低FA在左半球fronto-temporal-insular地区相对于控制。考虑ICVF,更严重的改变而FA地图可以找到svPPA和nfvPPA患者之间差异也。ICVF图分析措施还显示,svPPA较低学位中心和SN比控制在颞叶。
结论:这些发现表明,传统发表的措施可能会敏感到足以凸显FTLD频谱脆弱的连接。然而,ICVF证明是一个更具体的生物标记来区分FTLD综合症。具体来说,利益之间出现了分化svPPA病人和其他团体。
披露:Federica Agosta已收到个人薪酬在500 - 4999美元的范围在飞利浦的演讲人。Federica Agosta已收到个人薪酬在500 - 4999美元的范围作为一个编辑,副主编,或为爱思唯尔公司编辑顾问委员会成员。西尔维亚Basaia没有披露。Facente博士没有披露。Cividini女士没有披露。博士利沃诺主席没有披露。Elisa Canu的机构已经收到了来自意大利卫生部的研究支持。Castelnovo博士没有披露。朱塞佩•马格纳尼没有披露。卡索博士没有披露。Paola Caroppo没有披露。 Sara Prioni has nothing to disclose. Miss Villa has nothing to disclose. Lucio Tremolizzo has nothing to disclose. Dr. Appollonio has nothing to disclose. Dr. Silani has nothing to disclose. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for Bayer, Biogen Idec, Merck-Serono, Novartis, Roche, Sanofi Genzyme, Takeda, and Teva Pharmaceutical Industries. Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, Teva Pharmaceutical Industries, Italian Ministry of Health, Fondazione Italiana Sclerosi Multipla, and ARiSLA (Fondazione Italiana di Ricerca per la SLA).
