文摘
摘要目的:比较visually-rated macrostructural autopsy-confirmed CTE和参与者之间的功能核磁共振成像的广告。
背景:生物标记物,可以准确地检测神经退行性疾病慢性创伤性脑病(CTE)尚不存在。结构的MRI是不可或缺的组件的体内检测阿尔茨海默病(AD)和相关疾病,但目前不清楚用途确定CTE。CTE的MRI特征之前通过与正常相比,参与者认知特点。这些发现的特异性CTE(与其他神经退行性疾病)是不确定由于缺乏疾病比较像广告。
设计/方法:样本包括63名大脑捐助者autopsy-confirmed CTE 35参与者和广告(7 autopsy-confirmed 28 AD痴呆)。参与者都是雄性,≥60年。核磁共振成像是通过医疗记录。三个神经放射使用视觉等级量表(0 =没有,4 =严重)的速度萎缩T2-FLAIR T1和微血管疾病上。被评为腔透明隔(CSP)存在。多数使用评级;使用中值多数的缺失。协方差分析控制年龄MRI相比组织萎缩和微血管疾病的评级。二元逻辑回归用于缺席/ CSP。
结果:63 CTE, 56有很高的阶段和捐助者与CTE四年以下广告(71.51,SD = 7.7 vs 75.6, SD = 7.4)。与广告相比,CTE前颞叶萎缩较高评级(意味着diff = 1.01, 95% CI = 0.08 - -1.94)和5.2倍(95% CI = 1.02 - -26.90)增加几率CSP。有统计趋势更大的背外侧额叶萎缩(意味着diff = 0.88, 95% CI -1.81 = -0.06),更大的第三脑室(意味着diff = 0.46, 95% CI = -0.07 - -0.99),和更大的室周的(意味着diff = 0.39, 95% CI -0.83 = -0.05)和深层白质hyperintensities(意味着diff = 0.42, 95% CI = -0.05 - -0.89)在CTE。没有影响parietal-occipital和内侧颞叶,侧脑室,胼胝体或microbleeds (p > 0.10)。
结论:额颞叶萎缩和CSP MRI可以从广告促进CTE的鉴别诊断。
披露:Mosaheb小姐没有披露。面博士获得了个人作为一个雇员补偿波士顿成像的核心实验室。博士面受到个人补偿的范围为0 - 499美元在生原体的演讲人。面博士在波士顿股票成像核心实验室。博士面受到知识产权利益从发现或技术有关卫生保健。法里斯先生没有披露。凯伦Buch博士没有披露。布列塔尼人Asken没有披露。Rabinovici博士已经收到个人薪酬在10000 - 49999美元的范围为卫材担任顾问。Rabinovici博士已经收到个人薪酬在500 - 4999美元的范围为通用电气医疗集团担任顾问。Rabinovici博士已经收到个人薪酬在500 - 4999美元的范围为罗氏公司担任顾问。Rabinovici博士已经收到个人薪酬在500 - 4999美元的范围为基因泰克公司担任顾问。 Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Johnson & Joihnson. Dr. Rabinovici has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for JAMA Neurology. The institution of Dr. Rabinovici has received research support from NIH. The institution of Dr. Rabinovici has received research support from American College of Radiology. The institution of Dr. Rabinovici has received research support from Alzheimer’s Association. The institution of Dr. Rabinovici has received research support from Rainwater Charitable Foundation. The institution of Dr. Rabinovici has received research support from Genentech. Dr. Rabinovici has received personal compensation in the range of $5,000-$9,999 for serving as a Topic Chair, Course Director and teacher with AAN. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Grant reviewer with NIH. Madeline Uretsky has nothing to disclose. Yorghos Tripodis, 5406 has nothing to disclose. Brett Martin has nothing to disclose. Joseph Palmisano has nothing to disclose. Dr. Kowall has received publishing royalties from a publication relating to health care. Bertrand Huber has nothing to disclose. Robert Stern, PhD has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Biogen. The institution of Robert Stern, PhD has received research support from Eisai. The institution of Robert Stern, PhD has received research support from Lilly. The institution of Robert Stern, PhD has received research support from ATRI/NIA. Robert Stern, PhD has received publishing royalties from a publication relating to health care. Robert Stern, PhD has a non-compensated relationship as a Member with NFLPA Mackey-White Committee that is relevant to AAN interests or activities. Dr. Killiany has nothing to disclose. Dr. Stein has nothing to disclose. Dr. McKee has nothing to disclose. The institution of Dr. Mez has received research support from NIH, DOD. The institution of Michael Alosco, PHD has received research support from NIH.
