文摘
摘要目的:利用radiomics和机器学习识别集群焦女士急性病变表现出相似的空间和/或结构模式在传统的横断面(pre -和post-contrast) t1, t2加权,PD-weighted大脑核磁共振成像和天赋。
背景:多发性硬化(MS)病变表现出异质性的潜在的病理解剖位置和纵向演化。常规MRI对病变异质性的某些方面很敏感。无监督聚类方法可以识别亚型急性病变女士与特定的病理特点和帮助改善疾病描述和预测。
设计/方法:从推进审判大脑核磁共振成像(1512例复发缓和,女士NCT00906399)进行回顾性分析。对于每一个扫描,焦急性(钆增强和/或新的或显著放大)T2病灶(N = 3058)被确定在白质(WM)。每一个病变通过它的质心代表标准导弹- 152空间和radiomics-based结构属性。类似病变通过k - means聚类分组,分别应用在空间和每个sequence-specific结构域。集群计算优化的基于轮廓的分数,Davies-Bouldin指数和方差比例标准。
结果:最优聚类质量导致8原型WM网站出现病变,在每个post-contrast T1 - 3典型的结构模式,PD-weighted和天赋MRI和5模式在每个造影T1和t2加权磁共振成像。统计上显著的横向关联发现这些病变的发生之间的亚型和患者年龄、性别、年疾病发病和eds得分,通过逻辑回归分析(p < 0.05)。
结论:特定的空间和结构模式的急性病变女士被确定使用无监督聚类。进一步的工作将评估确定的临床相关性急性损伤模式向女士预测疾病进展的临床和MRI端点。每个病变的纵向动力学模式将通过测量调查未来的损伤修复或转向慢性活动/活动的损伤状态。
披露:卡巴先生已经收到Therapanacea的个人作为一个雇员补偿。卡巴先生已经收到生原体的个人作为一个雇员补偿。卡巴先生已经收到个人薪酬在50000 - 99999美元的范围与Therapanacea作为研究工程师。卡巴先生已经收到个人薪酬在100000 - 499999美元的范围作为一个科学家II, ML /人工智能与生原体。Gafson博士在生原体有股票。Ioannidou博士已经收到Therapanacea的个人作为一个雇员补偿。Xiaotong江泽民没有披露。伊丽莎白·费舍尔已经收到生原体的个人作为一个雇员补偿。伊丽莎白·费舍尔在生原体有股票。伊丽莎白·费舍尔已经收到知识产权利益从发现或技术有关卫生保健。 Dr. Arnold has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen. Dr. Arnold has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Celgene. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Frequency Therapeutics. Dr. Arnold has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Merck. Dr. Arnold has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Novartis. Dr. Arnold has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Roche. Dr. Arnold has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Shionogi. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Xfacto communications. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for EMD Serono. Dr. Arnold has stock in NeuroRx. Colm Elliott has received personal compensation for serving as an employee of NeuroRx Research. Nikos Paragios has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for AstraZeneca. Nikos Paragios has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Ipsen. Nikos Paragios has received personal compensation in the range of $500-$4,999 for serving as an officer or member of the Board of Directors for ArteDrone. Nikos Paragios has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Nikos Paragios has received intellectual property interests from a discovery or technology relating to health care. Nikos Paragios has received personal compensation in the range of $100,000-$499,999 for serving as a CEO with TheraPanacea. Dr. Belachew has received personal compensation for serving as an employee of Biogen Inc. Dr. Belachew has received stock or an ownership interest from Biogen Inc.
