文摘
摘要目的:本研究的目的是恢复3 d-t1加权多发性硬化(MS)患者的大脑核磁共振扫描复制的同源表示他们lesion-free大脑。
背景:在群体研究中,女士的大脑核磁共振成像的比较与合成lesion-free同行可能强调针对疾病的变化可能提供病理生理学女士见解。
设计/方法:生成敌对的网络(GAN)基于StyleGAN2训练来生成合成健康的大脑扫描512 -维潜变量。然后,每个大脑女士将这latent-space恢复潜变量,生成合成“健康”的大脑也是最类似于女士。
3500的3 d模型训练,t1加权健康成年人的大脑核磁共振成像在HCP汇集,OASIS2团队和数据集。进行评估,从预先扫描2398 MS患者(NCT00906399)和提升(NCT01416181)试验。所有扫描skull-stripped,重新取样2毫米各向同性体元间距,并通过min-max intensity-normalized映射到范围(−1,1)。
模型评价包括目视检查和定量措施:均方误差(MSE),结构的相似性度量(SSIM)和峰值信噪比(PSNR)最初的脑部扫描女士及其合成lesion-free之间,排除病变面具的地区。
结果:我们我们的方法应用于3 d t1加权核磁共振成像的MS患者恢复lesion-free大脑的各向同性决议2毫米。生成lesion-free脑部扫描显示病变并显示伟大的女士没有相似的大脑女士病变以外的地区,也突出了以下指标:SSIM = 0.99, PSNR值= 34.5,MSE = 1.49 e - 3。
结论:我们的方法重建的现实lesion-free表示3 d t1 MS患者的脑部核磁共振成像扫描。这种方法可以适用于其他神经系统疾病。
披露:SPINAT先生已经收到Therapanacea的个人作为一个雇员补偿。卡巴先生已经收到Therapanacea的个人作为一个雇员补偿。卡巴先生已经收到生原体的个人作为一个雇员补偿。卡巴先生已经收到个人薪酬在50000 - 99999美元的范围与Therapanacea作为研究工程师。卡巴先生已经收到个人薪酬在100000 - 499999美元的范围作为一个科学家II, ML /人工智能与生原体。Ioannidou博士已经收到Therapanacea的个人作为一个雇员补偿。Gafson博士在生原体有股票。Teboul博士没有披露。Xiaotong江泽民没有披露。Lepetit博士已经收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或数据安全监测委员会Therapanacea。 Dr. Arnold has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen. Dr. Arnold has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Celgene. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Frequency Therapeutics. Dr. Arnold has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Merck. Dr. Arnold has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Novartis. Dr. Arnold has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Roche. Dr. Arnold has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Shionogi. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Xfacto communications. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly. Dr. Arnold has received personal compensation in the range of $500-$4,999 for serving as a Consultant for EMD Serono. Dr. Arnold has stock in NeuroRx. Dr. Gabr has received personal compensation for serving as an employee of Biogen. Dr. Gabr has stock in Biogen. Enrica Cavedo has nothing to disclose. Colm Elliott has received personal compensation for serving as an employee of NeuroRx Research. Nikos Paragios has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for AstraZeneca. Nikos Paragios has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Ipsen. Nikos Paragios has received personal compensation in the range of $500-$4,999 for serving as an officer or member of the Board of Directors for ArteDrone. Nikos Paragios has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Nikos Paragios has received intellectual property interests from a discovery or technology relating to health care. Nikos Paragios has received personal compensation in the range of $100,000-$499,999 for serving as a CEO with TheraPanacea. Dr. Belachew has received personal compensation for serving as an employee of Biogen Inc. Dr. Belachew has received stock or an ownership interest from Biogen Inc.
