文摘
摘要目的:理解动脉内的溶栓的安全性和有效性保一群患者治疗血栓切除术。
背景:急性基底动脉闭塞(包)导致高发病率和死亡率。选择一个随机对照试验证明临床效益后动脉内的溶栓成功的机械血栓切除术相比安慰剂。研究需要了解这个试验的结果的普遍性和其他血管领土。
设计/方法:pc搜索业务是一个全国范围的回顾注册表连续急性保治疗血栓切除术与来自八大容量中心在美国从2015年7月- 2021年12月。病人被包含在这个注册表,如果他们收到机械血栓切除术或动脉内的溶栓在24小时内的最后一次看到正常。注册包括基线特征的数据,预处理和一种数据,影像学和临床结果。良好的临床结果被定义为≤3夫人。子群的患者用IA tPA治疗期间或之后血栓切除术相比,他们没有收到IA tPA的患者。逻辑回归进行评估IA tPA的安全。
结果:pc搜索业务登记了519名患者28例(5.4%)患者接受IA-tPA。IA tPA集团有相似的年龄中位数(66 vs 65, p = 0.82),署(18 vs 17, p值0.5),和第四的tPA管理局(21%比26%,p值0.48)无IA tPA组。其他基线特征是平衡的。百分之四十五的患者达到≤3夫人与总死亡率的41.4%,90天。多变量分析显示IA-tPA与症状性颅内出血(可信区间1.60 - 16.84或5.20;p = 0.006)。良好的临床结果没有影响IA-tPA (42 vs 45%, p值0.83)。
结论:动脉内溶栓与颅内出血急性基底动脉阻塞病人血栓切除术没有临床益处。
披露:Mierzwa博士没有披露。扎伊迪博士没有披露。Gharaibeh博士没有披露。Aladamat博士没有披露。Afreen博士没有披露。萨米艾尔卡萨伯没有披露。纳尔逊博士没有披露。奥尔特加古铁雷斯博士已经收到个人薪酬在10000 - 49999美元的范围为stryker担任顾问。奥尔特加古铁雷斯博士已经收到个人薪酬在10000 - 49999美元的范围为美敦力公司担任顾问。奥尔特加古铁雷斯博士已经收到个人薪酬在5000 - 9999美元的范围为microvention担任顾问。 Dr. Ortega Gutierrez has received personal compensation in the range of $0-$499 for serving as an officer or member of the Board of Directors for SVIN. The institution of Dr. Ortega Gutierrez has received research support from stryker. The institution of Dr. Ortega Gutierrez has received research support from Siemens. The institution of Dr. Ortega Gutierrez has received research support from IschemiaView. The institution of Dr. Ortega Gutierrez has received research support from Medtronic. Dr. Farooqui has nothing to disclose. Mr. Vivanco-Suarez has nothing to disclose. Dr. Jadhav has nothing to disclose. Dr. Desai has nothing to disclose. Dr. Toth has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Dynamed. Dr. Toth has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Microvention. Dr. Toth has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Medtronic. Dr. Alrohimi has nothing to disclose. Dr. Nguyen has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Vesalio. Dr. Nguyen has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for NIH. Dr. Nguyen has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Avania. Dr. Nguyen has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for AHA. The institution of Dr. Nguyen has received research support from Boston Medical Center. The institution of Dr. Nguyen has received research support from Society of Vascular and Interventional Neurology. Mr. Klein has nothing to disclose. Mohamad Abdalkader has nothing to disclose. Dr. Pandey has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for NIH and SVIN- Journal. Dr. Pandey has stock in FlexDex. Dr. Pandey has stock in NextGen. The institution of Dr. Pandey has received research support from NIH. The institution of Dr. Pandey has received research support from Focused ultrasound foundation. Dr. Pandey has received intellectual property interests from a discovery or technology relating to health care. Sravanthi Koduri has nothing to disclose. Vora Shivangi has nothing to disclose. Nirav Vora has nothing to disclose. Dr. Jumaa has nothing to disclose.
