文摘
摘要目的:(1)对阻塞性睡眠呼吸暂停综合症和小血管疾病严重程度之间的关系(圣)在缺血性中风患者/ TIA。(1)评估这些协会只可能出现在选择是否与特定类型的圣言的大脑区域。(2)研究阻塞性睡眠呼吸暂停综合症之间的关系,计算和认知。
背景:脑小血管疾病(圣)是血管性痴呆的最常见原因。在MRI圣言会表现为白质Hyperintensities(负责人),可见,扩大血管周的空间和microbleeds。阻塞性睡眠呼吸暂停(OSA)是最常见的睡眠障碍和整合数据支持阻塞性睡眠呼吸暂停综合症之间的关系和计算。本研究的目的是检查之间的关系:(1)阻塞性睡眠呼吸暂停综合症严重程度和奇异值分解(2)阻塞性睡眠呼吸暂停综合症的严重性,圣言与认知。
设计/方法:缺血性中风/ TIA患者前瞻性招募在三个独立的队列研究。多年的教育、血管危险因素、中风严重性和蒙特利尔认知评估分数收集。所有患者MRI和完成一个在实验室多导睡眠图(PSG)或家庭睡眠呼吸暂停测试(HSAT)。阻塞性睡眠呼吸暂停综合症的严重程度量化使用呼吸暂停指数(AHI)。小血管疾病的负担是量化使用视觉等级量表进行验证。顺序逻辑回归模型对阻塞性睡眠呼吸暂停综合症之间的关系和计算,同时为协变量控制。
结果:在237例增加AHI与更大负担的室周的负责人(pWMH)或= 1.02 (CI: 1.01 - 1.04, p = 0.02),深microbleeds或= 1.03 (CI: 1.01 - 1.05, p = 0.002)和大叶性microbleeds = 1.02 (CI: 1.01 - 1.04, p = 0.03)。最后,在一个有序逻辑回归模型,较低的认知成绩相关脑microbleeds或= 1.09 (CI: 1.01 - 1.18, p = 0.03),同时为协变量控制。
结论:阻塞性睡眠呼吸暂停综合症的严重程度与更大的室周的相关负责人和大脑microbleeds。脑microbleeds预测认知得分越低。阻塞性睡眠呼吸暂停综合症的关系大叶性和深microbleeds表明潜在的关联与夜间高血压和脑淀粉样间隙。
披露:缪尔博士没有披露。Dharmakulaseelan女士没有披露。黑色博士已经收到个人薪酬在5000 - 9999美元的范围为罗氏公司担任顾问。黑色博士已经收到个人薪酬在500 - 4999美元的范围作为顾问生原体。黑色博士已经收到个人薪酬在5000 - 9999美元的范围为在科学咨询服务或数据安全监测对罗氏公司董事会。黑色博士已经收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或数据安全监测委员会生原体。黑色博士已经收到个人薪酬在10000 - 49999美元的范围在生原体的演讲人。黑博士的机构收到罗氏公司的研究支持。黑博士的机构收到生原体的研究支持。黑博士的机构已收到研究通用电气医疗集团的支持。 The institution of Dr. Black has received research support from Eli Lilly. The institution of Dr. Black has received research support from Genentech. The institution of Dr. Black has received research support from NovoNordisk. The institution of Dr. Black has received research support from UCB Biopharma. The institution of Dr. Black has received research support from Alkahest Inc. The institution of Dr. Black has received research support from University of Southern California - AHEAD 3-45 Study. The institution of Dr. Murray has received research support from Wake Up Narcolepsy. Dr. Murray has received publishing royalties from a publication relating to health care. Dr. Boulos has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Jazz Pharmaceuticals. Dr. Boulos has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Paladin Labs. Dr. Boulos has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai. Dr. Boulos has received research support from Interaxon. The institution of Dr. Boulos has received research support from The Mahaffy Family Research Fund. The institution of Dr. Boulos has received research support from Canadian Institutes of Health Research. The institution of Dr. Boulos has received research support from Slamen-Fast New Initiatives in Neurology Award. The institution of Dr. Boulos has received research support from Green Mountain . Dr. Boulos has received personal compensation in the range of $5,000-$9,999 for serving as a speaker with Jazz Pharmaceuticals.
