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2023年7月18日 ;101 (3) 金博宝手机版官网首页 开放获取

慢性肾病协会与等离子体NfL和其他神经退化的生物标志物

在哥德堡H70出生队列研究

安娜>,视图ORCID概要尼古拉斯·j·阿什顿,视图ORCID概要Henrik Zetterberg,视图ORCID概要Kaj Blennow,安娜Zettergren,视图ORCID概要乔尔Simren,托拜厄斯Skillback,萨拉·夏姆斯,Alejandra马查多,视图ORCID概要埃里克·韦斯特曼,视图ORCID概要迈克尔肖勒,英格玛·斯库,Silke Kern
第一次出版2023年5月24日, DOI: https://doi.org/10.1212/WNL.0000000000207419
安娜>
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
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尼古拉斯·j·阿什顿
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
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Henrik Zetterberg
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
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  • Henrik Zetterberg ORCID纪录
Kaj Blennow
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
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  • ORCID记录Kaj Blennow
安娜Zettergren
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
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乔尔Simren
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
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  • 乔尔Simren ORCID纪录
托拜厄斯Skillback
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
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萨拉·夏姆斯
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
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Alejandra马查多
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
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埃里克·韦斯特曼
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
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  • 埃里克·韦斯特曼ORCID纪录
迈克尔肖勒
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
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英格玛·斯库
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
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Silke Kern
从神经流行病学单位(公元,A.Z.,t。s。,安全火花型,S.K.), Sahlgrenska Academy, University of Gothenburg; Department of Psychiatry Cognition and Old Age Psychiatry (A.D., I.S., S.K.), Sahlgrenska University Hospital, Mölndal; Department of Psychiatry and Neurochemistry (N.J.A., H.Z., K.B., J.S., M.S.), Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Mölndal Campus, Sweden; King's College London (N.J.A.), Institute of Psychiatry, Psychology and Neuroscience, Maurice Wohl Institute Clinical Neuroscience Institute; NIHR Biomedical Research Centre for Mental Health and Biomedical Research Unit for Dementia at South London and Maudsley NHS Foundation (N.J.A.), London, UK; Centre for Age-Related Medicine (N.J.A.), Stavanger University Hospital, Norway; Clinical Neurochemistry Laboratory (H.Z., K.B., J.S.), Sahlgrenska University Hospital, Mölndal, Sweden; UK Dementia Research Institute at UCL (H.Z.); Department of Neurodegenerative Disease (H.Z., M.S.), UCL Institute of Neurology, London, UK; Hong Kong Center for Neurodegenerative Diseases (H.Z.), China; Care Sciences and Society (S.S.), Karolinska Institutet, and Department of Radiology; Department of Clinical Neuroscience (S.S.), Karolinska University Hospital, Stockholm, Sweden; Department of Radiology (S.S.), Stanford University, CA; Division of Clinical Geriatrics (A.M., E.W.), Department of Neurobiology, Care Sciences and Society (NVS), Karolinska University Hospital; Division of Insurance Medicine (A.M.), Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; Department of Neuroimaging (E.W.), Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, Kings College London, UK; and Wallenberg Center of Molecular and Translational Medicine (M.S.), University of Gothenburg, Sweden.
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慢性肾病协会与等离子体NfL和其他神经退化的生物标志物
在哥德堡H70出生队列研究
安娜>,Nicholas J。艾什顿,亨瑞克Zetterberg,KajBlennow,安娜Zettergren,乔尔Simren,托拜厄斯Skillback,莎拉沙姆斯,Alejandra马查多,埃里克韦斯特曼,迈克尔肖勒,英格玛·斯库,Silke克恩
首页 2023年7月, 101年 (3) e277-e288; DOI:10.1212 / WNL.0000000000207419

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  • Flowchart of the Inclusion Process for the Study
    " data-icon-position="" data-hide-link-title="0">图1
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    图1 研究包含过程的流程图
  • Structural MRI Measurements and CSF Biomarkers in Participants Without and With CKD Structural MRI measurements of cerebral regions related to neurodegeneration presented for participants without and with CKD (A–D). Mean cortical thickness (A), mean lateral ventricular volume (B), mean hippocampal volume (C), and total white matter lesion volume (D) were measured. CSF biomarkers related to neurodegeneration were also analyzed (E–H). Aβ42/40-ratio (E), t-tau (F), p-tau (G), and NfL (H) in CSF were measured in participants without and with CKD. n = 744 in panel A–D (No CKD = 668, CKD = 76) and n = 313 in panel E–H (No CKD = 287, CKD = 26). The Mann-Whitney U-test was used for groupwise comparisons. NfL = neurofilament light protein; p-tau = phosphorylated tau; t-tau = total tau.
    " data-icon-position="" data-hide-link-title="0">图2
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    图2 结构磁共振成像测量和脑脊液生物标志物在参与者和慢性肾病

    结构的MRI测量神经退化相关的大脑区域提出了参与者没有和CKD(模拟)。意思是皮质厚度(A),意味着侧心室体积(B),意味着海马体积(C),和白质病变总额(D)测量。脑脊液生物标记物与神经退化也分析(情况)。Aβ42/40-ratio (E), t-tau (F), p-tau (G),和CSF NfL (H)测定在参与者和慢性肾病。在小组模拟n = 744(没有CKD = 668, CKD = 76)和n = 313面板超高频(没有CKD = 287, CKD = 26)。的Mann-WhitneyU以及用于groupwise比较。NfL =光神经丝蛋白;p-tau =磷酸化τ;t-tau =总τ。

  • Associations Between P-NfL and Kidney Function, Stratified by CKD and Dementia Scatterplot of P-NfL and eGFR in the study participants (n = 743, 1 outlier was not included in the figure, but was included in the statistics, n = 744), with linear regression curves stratified by CKD status (no CKD, n = 668 and CKD, n = 76) (A). Kidney function measured as eGFR (B) and P-NfL levels (C) in participants without cognitive impairment (CDR = 0), stratified by CKD status (no CKD, n = 540 and CKD, n = 62), and in participants with dementia and normal kidney function (n = 9). Linear regression lines in figure A were performed on untransformed P-NfL values to allow for the presentation of clinically relevant data in the panel. Groupwise comparisons were performed with the Kruskal-Wallis test. eGFR = estimated glomerular filtration rate; NfL = neurofilament light protein; P = plasma.
    " data-icon-position="" data-hide-link-title="0">图3
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    图3 P-NfL之间的关联和肾脏功能,分层CKD和痴呆

    P-NfL散点图和表皮生长因子受体的研究参与者(n = 743, 1例外是不包括在图中,而是包含在统计,n = 744),与线性回归曲线分层CKD状态(没有CKD, n = 668, CKD, n = 76) (A),肾功能测量表皮生长因子受体(B)和P-NfL水平(C)在参与者认知障碍(CDR = 0),分层的CKD状态(没有CKD, n = 540, CKD, n = 62)、和参与者与痴呆和正常肾功能(n = 9)。在图上进行线性回归直线untransformed P-NfL值允许临床相关数据的显示面板。Groupwise与克鲁斯卡尔-沃利斯检验进行比较。表皮生长因子受体=估计肾小球滤过率;NfL =光神经丝蛋白;P =等离子体。

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