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July 25, 2023; 101 (4) Contemporary Issues in Practice, Education, & Research

Should the Criterion for Brain Death Require Irreversible or Permanent Cessation of Function? Irreversible

The UDDA Revision Series

View ORCID ProfileAri R. Joffe
First published July 10, 2023, DOI: https://doi.org/10.1212/WNL.0000000000207403
Ari R. Joffe
From the Division of Critical Care Medicine (A.R.J.), Department of Pediatrics, and John Dossetor Health Ethics Center (A.R.J.), University of Alberta, Edmonton, Canada.
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Should the Criterion for Brain Death Require Irreversible or Permanent Cessation of Function? Irreversible
The UDDA Revision Series
Ari R. Joffe
Neurology Jul 2023, 101 (4) 181-183; DOI: 10.1212/WNL.0000000000207403

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Abstract

I argue that death is irreversible and not merely permanent. Irreversible means a state cannot be reversed and entails permanence. Permanent means a state will not be reversed and includes cases where the state could still be reversed though a decision has been made not to attempt this reversal. This distinction is important, as we shall see. Four reasons are given for why death must be irreversible and not merely permanent: no mortal can return from the state of death; unacceptable implications regarding culpability for actions and omissions; death is a physiologic state; and irreversibility is inherent in the standards to diagnose brain death. Four objections are considered including the following: permanence is the medical standard, permanence was the intent of the President's Commission on defining death, irreversible requires many hours to occur, and we should change terminology to reflect our case intuition. These objections are discussed and rejected. Finally, I clarify my views to conclude that the criterion for biological death is irreversible loss of circulation.

Glossary

BD=
brain death;
E-CPR=
extracorporeal cardiopulmonary resuscitation;
EPR=
emergency preservation and resuscitation

Footnotes

  • Go to Neurology.org/N for full disclosures. Funding information and disclosures deemed relevant by the authors, if any, are provided at the end of the article.

  • Submitted and externally peer reviewed. The handling editor was Editor-in-Chief José Merino, MD, MPhil, FAAN.

  • See page 184

  • Received December 14, 2022.
  • Accepted in final form March 28, 2023.
  • © 2023 American Academy of Neurology
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  • Article
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    • Introduction
    • Why Death Is Irreversible, Not Merely Permanent
    • Some Objections Considered
    • Some Clarification of My Views
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