可能的环境,职业,和其他帕金森病的病因学的因素

文摘

在病例对照研究中,我们调查了可能的病因学的相关性帕金森病(PD)的农村农业活动等因素,农药暴露,井水饮酒,和动物接触;毒素的暴露,如木材防腐剂,重金属,和溶剂;全身麻醉;头部外伤;并在子宫内的环境差异。我们招募了380名患者在9个德国诊所,379附近的对照组,376年最大的区域对照组病例对照研究等因素进行调查和收集的数据结构化面谈使用条件逻辑回归教育地位和控制吸烟。后者强烈反向与帕金森病有关。有明显升高的优势比(或)对农药的使用,特别是对有机氯和烷基化磷酸盐,但出现PD和其他农村之间没有联系的因素。显著升高或出现接触木材防腐剂。的渊源者的主观评价表明,接触一些重金属、溶剂、废气,和一氧化碳明显比对照组更频繁的患者,但这不是证实了一个平行的评估工作历史根据的工作接触矩阵。 Patients had undergone general anesthesia and suffered severe head trauma more often than control subjects, but a dose-response gradient was not present. Patients reported a significantly larger number of amalgam-filled teeth before their illness than control subjects. The frequency of premature births and birth order did not differ between patients and control subjects. Patients reported significantly more relatives affected with PD than control subjects. These results support a role for environmental and genetic factors in the etiology of PD.