This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased.
Cerebral cavernous malformation (CCM; MIM 116860) is a common disorder that is found in 0.1 to 0.5% of the population and represents ∼10 to 20% of cerebral vascular lesions.1 However, symptomatic disease is considerably less common. The lesions, which affect the brain vasculature, are characterized by abnormally enlarged capillary cavities in the brain without intervening normal parenchyma.2 Most often, CCM occurs sporadically, and individuals develop only one malformation. In familial CCM, the disorder is dominantly inherited, and individuals often develop multiple malformations. Symptoms include focal neurologic signs, hemorrhagic strokes, seizures, headaches, or sometimes death.1 Patients are treated conservatively or with surgical resection when lesions cause recurrent hemorrhage or seizures.
Three genetic loci have been defined:3 CCM1 on chromosome 7q21-q22 accounting for 40% of all familial cases, CCM2 on 7p13-p15 accounting for 20%, and CCM3 on 3q25.2-q27 for 40%. Subsequently, the CCM1 gene has been identified and has been shown …
AAN Members
We have changed the login procedure to improve access between AAN.com and the Neurology journals. If you are experiencing issues, please log out of AAN.com and clear history and cookies. (For instructions by browser, please click the instruction pages below). After clearing, choose preferred Journal and select login for AAN Members. You will be redirected to a login page where you can log in with your AAN ID number and password. When you are returned to the Journal, your name should appear at the top right of the page.
AAN Non-Member Subscribers
Purchase access
Letters: Rapid online correspondence
REQUIREMENTS
You must ensure that your Disclosures have been updated within the previous six months. Please go to our Submission Site to add or update your Disclosure information.
Your co-authors must send a completed Publishing Agreement Form to Neurology Staff (not necessary for the lead/corresponding author as the form below will suffice) before you upload your comment.
If you are responding to a comment that was written about an article you originally authored:
You (and co-authors) do not need to fill out forms or check disclosures as author forms are still valid
and apply to letter.
Submission specifications:
- Submissions must be < 200 words with < 5 references. Reference 1 must be the article on which you are commenting.
- Submissions should not have more than 5 authors. (Exception: original author replies can include all original authors of the article)
- Submit only on articles published within 6 months of issue date.
- Do not be redundant. Read any comments already posted on the article prior to submission.
- Submitted comments are subject to editing and editor review prior to posting.
