文摘
摘要目的:定义一个协调协议手册海马分割从磁共振扫描。
背景异质性的地标在协议导致不同体积的估计,阻碍的比较研究和临床使用。具有里程碑意义的差异提取12种最常见的协议,实施,定量调查。Delphi面板提供的结果,由17个研究人员与大量专业知识在海马分割,分割地标达成以证据为基础的共识。
设计/方法:Delphi小组参与匿名投票会议,反馈递归前几轮利用逐步促进小组成员的协议。小组成员与跟踪方案,提出了每个与相关的定量数据:(i)的可靠性,对整个海马体积(ii)的影响,并与AD病理(iii)的相关性。小组成员被要求选择备选方案并提供理由和评论。匿名投票和评论,投票统计的第一轮被送入第二轮Delphi。精确概率二项测试的选择计算。在撰写本文时,两轮德尔菲完成。
结果:16个小组成员完成Delphi轮。协议是重要包含alveus和伞(81%,p = 0.021),整个可见海马尾巴(75%,p = 0.035),和接近意义的内侧边界分割的身体后可见形态(69%,p = 0.057)。协议包括最低的海马体,alveus,形态菌丝层,整个海马尾巴在最后海马跟踪协议很重要(88%,p = 0.001)。以前的定量调查的基础上具有里程碑意义的差异,海马体所以定义覆盖100%的海马组织,捕获AD-related萎缩的100%,并有很好的intra-rater(0.99)和两分(0.94)可靠性测量体积统计数据。
结论:最“包容性”地标被德尔菲专家首选。进一步轮将寻求各方面统计上显著的协议。
支持:阿尔茨海默氏症协会。礼来国际。辉瑞惠氏国际(集团)。
披露:Boccardi博士没有披露。Bocchetta博士没有披露。Apostolova博士没有披露。Barnes博士没有披露。Bartzokis博士已经收到个人补偿活动与百时美施贵宝公司和诺华公司。Bartzokis博士接到诺华和杨森制药研究支持。Corbetta博士没有披露。DeCarli博士已经收到个人补偿活动xxx默克制药、Avanir,拜耳制药和辉瑞consultant.Dr。DeCarli已收到个人薪酬在一篇社论中阿尔茨海默氏症和相关Disorders.Dr的能力。DeCarli已收到从默克研究支持。 Dr. DeToledo-Morrell has nothing to disclose. Dr. Firbank has nothing to disclose. Dr. Ganzola has nothing to disclose. Dr. Gerritsen has nothing to disclose. Dr. Henneman has nothing to disclose. Dr. Killiany has received personal compensation for activities with Sunovion Pharmaceuticals Inc as a consultant. Dr. Killiany has received research support from The MRI Centers of New England and a clinical affiliation with Essex Neurological Associates. Dr. Malykhin has nothing to disclose. Dr. Pasqualetti has nothing to disclose. Dr. Pruessner has nothing to disclose. Dr. Redolfi has nothing to disclose. Dr. Robitaille has nothing to disclose. Dr. Soininen has received personal compensation for activities with ACImmune. Dr. Tolomeo has nothing to disclose. Dr. Wang has nothing to disclose. Dr. Watson has nothing to disclose. Dr. Wolf has nothing to disclose. Dr. Duchesne has received (royalty or license fee or contractual rights) payments from Screen Inc.Dr. Duchesne has received research support from Afga Healthcare Inc. Dr. Jack has received personal compensation for activities with Janssen Pharmaceutica, Eisai Inc, General Electric, Johnson and Johnson, and Eli Lilly & Company as a consultant.Dr. Jack has received research support from Pfizer Inc, Allon, and Baxter, Inc. Dr. Frisoni has received personal compensation for activities Eli Lilly & Company, Bristol-Myers Squibb Company, Bayer Healthcare, Lundbeck Research USA, Inc., Elan Corporation, AstraZeneca Pharmaceuticals, Pfizer Inc, Baxter, Taurx, and Wyeth Pharmaceuticals. Dr. Frisoni has received personal compensation in an editorial capacity for Lancet Neurology, Aging Clinical & Experimental Research, Neurobiology of Aging, Alzheimer's Diseases and Associated Disorders, and Neurogenerative Diseases. Dr. Frisoni has received research support from Wyeth Corporation, Eli Lilly & Company, Lundbeck Research USA, Inc.
2012年4月24日,星期二,下午13:00 pm-14:45
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