¹⁸氟脱氧葡萄糖正电子发射断层扫描脊髓代谢亢进歧视肿瘤的炎症性脊髓病(P06.142)

文摘

摘要目的:探讨脊髓的使用¹⁸F-Fluorodeoxyglucose正电子发射断层扫描(正)患者的脊髓病的不确定的病因。

背景:脊髓摄影是一个可能的工具评估治疗脊髓炎的不确定的病因。我们假设正代谢亢进可能从炎症病因鉴别肿瘤脊髓炎。

设计/方法:我们回顾性梅奥诊所患者从1996 - 2011年脊髓病由于脊髓髓内病变诊断正被执行。压患者骨髓脊髓炎,辐射脊髓病或慢性脊髓炎与已知的病因被排除在外。51例患者包括(53%的女性)的平均年龄60年(20 - 82年)。患者肿瘤或炎症病因non-neurosarcoid一分为二。Neurosarcoid脊髓炎摄影hypermetabolic先天的因此分别进行了分析。两个放射科医生独立评估摄影在代谢亢进和最大标准摄入值(SUVmax)盲底层脊髓病病因。

结果:脊髓与肿瘤代谢亢进是更常见的脊髓病(17/21;81%)比炎症性脊髓病(6/24;25%)(p < 0.001)。此外,中位数SUVmax在肿瘤大于炎症性脊髓病的原因(3.3 g / ml vs 1.9 g / ml;p < 0.001)。放射科医生的评估之间的协议是优秀的(Κ= 0.88)。炎症性脊髓病诊断(n = 24)是:自身免疫性/其他5、多种13日炎性脱髓鞘4,横向脊髓炎2。肿瘤诊断(n = 21)是:髓内转移12;髓内淋巴瘤/白血病7;和主髓内肿瘤2。 Six patients had neurosarcoid myelopathy. FDG-PET hypermetabolism was seen in three patients with neurosarcoid myelopathy (median SUVmax 2.6 g/ml; range, 1.8-12.2).

结论:脊髓摄影代谢亢进更常见肿瘤脊髓炎的炎症性脊髓炎和可能是有用的在评估脊髓病的不确定病因区别肿瘤炎症病因。

披露:弗拉纳根博士没有披露。亨特博士没有披露。劳博士收到拜耳医药咨询个人赔偿。劳博士收到通用电气医疗、研究资助西门子分子成像,AVID Radiopharmaceuticals, Inc . Mandrekar博士没有披露。Pittock博士和梅奥诊所有经济利益在技术题为“Neuromyelitis视自身抗体作为肿瘤的标记。”This technology has been licensed to a commercial entity but no royalties have been received. Dr Sean Pittock has received research support from Alexion Pharmaceuticals, Inc. Dr. O'Neill has received personal compensation for activities with McGraw-Hill. Dr. O'Neill has received personal compensation in an editorial capacity for Neuro-oncology. Dr. O'Neill has received compensation for serving on the Board of CellDex Data Safety Monitoring Board. Dr. O'Neill holds stock and/or stock options in Johnson & Johnson. Dr. Keegan has received personal compensation for activities with BIONEST Partners and Glaxo-Smith-Klein as a consultant. Dr. Keegan received compensation as a section editor for Neurology. Dr. Keegan has received research support from Caridian BCT.