临死前的磁共振成像结果与微型心肌梗塞的可能性尸检(S49.007)

文摘

摘要目的:调查是否临死前的核磁共振研究的宏观脑血管疾病与微型心肌梗塞的可能性尸检的存在有关。

背景:阿尔茨海默病后,微型心肌梗塞的可能性是第二个最常见的病理尸检和与老年认知障碍和痴呆。这些微小病变MRI常规临死前的不可见。相反,宏观损伤与脑血管疾病是可见的在临死前的t2加权MRI或液体衰减反转恢复(天赋)。

设计/方法:病人(n = 18)与一个或多个微型心肌梗塞的可能性在解剖进行了MRI三年前死亡2:1倾向与没有微型心肌梗塞的可能性(n = 36)患者年龄、性别、教育和病理诊断。白质hyperintensity(负责人)卷计算从天赋使用半自动图像分割算法引用到白色物质总量。宏观皮层和皮层下梗死灶在天赋MRI视觉评估。全脑萎缩和心室容积变化对临死前的纵向MRI计算使用边界积分法转变在t1扫描至少两年分开。

结果:存在和皮层下(p = 0.03)和皮质梗死灶(p = 0.02)在临死前的MRI与微型心肌梗塞的可能性死后的存在。微型心肌梗塞患者表现出更大的利率的趋势(p = 0.09)全脑萎缩患者比没有微型心肌梗塞的可能性尸检。总分数负责人(p = 0.18)和心室容积增加(p = 0.27)相比没有显著的患者的微型心肌梗塞的可能性更大,患者没有微型心肌梗塞的可能性。

结论:存在和MRI上的皮质和皮质下梗死灶数量与微型心肌梗塞的可能性尸检的存在。这些数据表明,类似血管疾病机制负责标识的皮层和皮层下梗死灶在临死前的MRI和尸检确定微型心肌梗塞的可能性。

支持:P50 -AG016574R01 -AG040042R01 -AG011378U01 -AG006786;罗伯特·h·史密斯和克拉丽斯和阿比盖尔vanBuren广告研究项目。

披露:拉曼博士没有披露。Preboske博士没有披露。Przybelski博士没有披露。甘特博士没有披露。Senjem博士没有披露。墨菲博士没有披露。莫瑞没有披露。Boeve博士收到头研究支持公司。Allon疗法;和通用电气医疗集团。 Dr. Knopman has received personal compensation for activities with Eli Lilly & Company. Dr. Knopman has received personal compensation in an editorial capacity for Neurology. Dr. Knopman has received research support from TauRx. Dr. Petersen has received personal compensation for activities with Pfizer, Inc., Janssen Alzheimer's Immunotherapy, Elan Pharmaceuticals, GE Healthcare, and Novartis. Dr. Parisi has nothing to disclose. Dr. Dickson has received personal compensation for activities with Neotope, Inc. as a consultant. Dr. Jack has received personal compensation for activities with Janssen, Eisai Inc., General Electric, Johnson & Johnson, and Eli Lilly & Company. Dr. Jack has received research support from Pfizer Inc, Allon, and Baxter. Dr. Jack has received research support from Allon and Baxter. Dr. Kantarci has received compensation from Takeda Global Research & Development Center for serving as an advisory board member for research support.