自发的瞳孔虹膜震颤患者明显抑制特发性帕金森病(P6.042)

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摘要目的:探讨瞳孔虹膜震颤的角色作为一个潜在的生物标志物的特发性帕金森病(PD)。背景:自主和其他神经系统显示PD患者逐步退化。我们假设,随着神经系统的退化,导致虹膜震颤和复杂的相互作用自发振荡自己会变得更简单。设计/方法:我们回顾了自发振荡瞳孔8 PD患者在疾病的不同阶段(56 - 86年的平均71岁)和11个神经疾病患者进行测试,因为异常眼球运动(年龄35 - 84平均56)。最常见的诊断是眼球震颤不清楚病因。瞳孔的大小所有病人被记录在同一个房间里相同的照明使用红外video-oculography在240赫兹。所有被要求注视一个小目标1米2分钟。眨眼构件消除使用一个定制的Matlab程序。二十秒工件使用免费样品进行分析。使用瞳孔虹膜震颤是量化动荡指数(PUI)作为描述(M。沃加et al ., 2009)。 Results: Pupil size in the two groups was not statistically different, but PD were slightly older than controls (p< 0.05). The range of PUI for the controls was 2.92-5.23mm/min (mean 3.84mm/min, std 0.91). The range of PUI for PD patients was 0.43-0.86mm/min (mean 0.71mm/min, std 0.16). A 2-tailed t-test showed significance at p=0.0000014. A twelfth control patient was excluded when he was found to have a diagnosis of PSP. His PUI was similar to those in the PD group at 0.86mm/min. Conclusions: Although our groups were small, there was no overlap in PUI between PD and patients with other neurologic diseases using only a 20 second pupillary recording. This suggests the evaluation of hippus may play an important role in the evaluation of patients with PD and other basal ganglia disorders.

披露:Mangipudi博士没有披露。Cristini博士没有披露。汉娜博士已经收到个人活动与补偿Teva神经科学,葛兰素史克,Inc .和Lundbeck公司研究美国,它是一家公司作为一个顾问委员会成员和/或扬声器。罗森博格博士没有披露。