感染入院时和中风的年轻(P3.230)

文摘

目的:确定感染的独立影响出现在入学(IPOA)年轻的中风患者的结果。背景:前期感染已确定中风的危险因素和触发器,而卒中后感染导致更糟糕的结果。方法:回顾性研究连续18到40岁的缺血性中风患者承认01/08-06/14之间进行。IPOA被定义为存在如果感染被诊断出的第一个24小时内入院。主要结果中风严重性使用美国国立卫生研究院的中风尺度(署)和改良Rankin在放电规模(夫人)3 - 6。结果:235例,41 (17.4 [percnt]) IPOA。IPOA患者更有可能是女性(87.8 (percnt)和51.0 (percnt);p < 0.0001),年轻(30与34年;p = 0.0317)和高署(平均4和2;p = 0.029)。 The effect of age on the relationship between IPOA and outcomes appeared to be an interaction, however, the sample size is small; therefore analyses stratified on age were conducted to assess the relationship between IPOA and outcomes. Among patients 18-30, those with IPOA had NIHSS scores 6 points higher than those without IPOA after adjusting for age and sex (p=0.0039), whereas there was no relationship between IPOA and NIHSS in patients > 30 years. In patients 18-30, after adjusting for age, sex, and NIHSS, IPOA was associated with a greater odds of poor outcome (OR 3.69, 95[percnt]CI 1.20-11.3). IPOA was not significantly associated with poor outcome after adjusting for age, sex and NIHSS in patients >30 years (OR 1.29, 95[percnt]CI 0.48-3.51). Discussion: IPOA in young stroke patients are closely associated with NIHSS and subsequent poor outcomes at discharge. Further studies are needed to understand the role of infection and whether infections moderate the effect of stroke severity on stroke outcomes in young patients.

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