脑灌注和痴呆的风险一般人群(P4.002)

文摘

目的:确定脑灌注和痴呆的风险之间的联系。背景:脑灌注不足与脑萎缩有关各横断面研究和认知,和可能是一个有前途的目标预防痴呆。然而,它仍不确定是否低灌注之前认知能力下降或仅仅是由于萎缩代谢需求下降的结果。方法:在鹿特丹进行以人群为基础的研究中,我们测量二维相位对比MRI脑血流量的非痴呆的参与者。灌注计算流在mL / 100克/分钟。我们使用Cox风险模型来确定痴呆的风险与灌注,颅内总量,调整年龄、性别、心血管危险因素和APOE基因型。我们重复分析阿尔茨海默氏症,并排除那些中风或> 50 percnt颈动脉狭窄。最后,我们决定认知评估得分恶化电池在连续两个考试,与灌注。结果:4744名参与者(均数±63.6±10.8岁,55.2 [percnt]女性)与一个平均4.9年的随访中,82名参与者患上痴呆,其中59 (72.0 [percnt])阿尔茨海默氏症。那些高脑灌注患痴呆症的风险较低(95 [percnt] CI,调整人力资源,SD增加0.69,0.53 - -0.90;p = 0.006),和阿尔茨海默氏症(aHR 0.65, 0.48 -0.89; p = 0.008)。 This was similar after excluding those with stroke or >50[percnt] carotid artery stenosis, and similar after excluding dementia cases occurring within 3 years of follow-up. Amongst 3224 alive and non-demented participants whose follow-up extended beyond the next examination round (after on average 5.9 years), higher cerebral perfusion at baseline was associated with less decline in global cognition (p=0.02). Conclusion: Cerebral hypoperfusion is associated with an increased risk of cognitive decline and dementia in the general population. These findings suggest preservation and restoration of cerebral perfusion may limit cognitive decline.

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