的患病率和预后患者心室扩大(P4.034)

文摘

目的:Ventriculomegaly associates随着年龄的增长,退化性疾病、血管和先天性因素。梅奥诊所研究衰老的,基于人口的研究开始于2004年,包括非精神错乱的人70到89每15个月。我们评估了ventriculomegaly患病率和认知和步态的预后。方法:我们回顾了1794年基线ventriculomegaly核磁共振成像,大脑皮层萎缩,紧沟,裹入沟,白质改变。一个埃文斯指数≥0.3定义的心室扩大。我们确定了三组:脑积水没有萎缩(H),脑积水前真空(HEV)和控制(C)。我们比较组基线和利率的变化对GaitRite措施,定时25脚走路,统一帕金森病评定量表步态物品和认知措施(注意力、语言、记忆和视觉空间的和全球的分数),和基线血管危险负担。结果:H患病率为8.9 (percnt)和戊肝病毒5.7 [percnt]。H是常见的男性比女性(11.7 [percnt]) (5.8 [percnt])。基线步态UPDRS分数> 1的比例是高H (p = 0.036)和戊肝病毒比控制(p = 0.028)。折合成年率的步态变化和全球GaitRite也高H (p = 0.07和0.002)和戊肝病毒(p = 0.001, p = 0.001)。 After 7 years , the proportion with gait UPDR>1 increased from 35 to 70[percnt] in H, 45 to 80[percnt] in HEV, and 25 to 45[percnt] in controls. Baseline cognitive scores were all significantly lower in H (all p≤0.006) and HEV (all p≤0.018). Cognitive decline rate was faster in H (p<0.001), but not in HEV (p=0.16). Vascular disease burden was more common in H (p=0.048) but not HEV (p=0.13). Conclusions: Ventriculomegaly is common in persons over 70 (8.9[percnt]), more common in men (11.7[percnt]), and associated with gait abnormality, cognitive impairment and decline of both. It is associated with vascular risk burden. These associations indicate ventriculomegaly may be an important biomarker of quality of life.

披露:Graff-Radford博士已经收到个人活动与补偿科德曼作为科学顾问委员会成员和Cytox顾问。琼斯博士没有披露。甘特博士没有披露。托马斯博士没有披露。克鲁克博士没有披露。Boeve博士已经收到个人活动与伊希斯医药补偿。Boeve博士已经收到药品研究通用电气医疗集团的支持和论坛。Knopman博士已经收到个人补偿活动Lundbeck公司药品它是一家。Knopman博士已经收到了个人在一篇社论中补偿神经病学的能力。首页Knopman博士收到礼来制药和Ta杰克博士研究支持已收到个人赔偿与詹森研发活动,公司通过提供咨询服务。 Dr. Jack has received research support from the National Institutes of Health (R01-AG011378, RO1-AG041851, RO1-AG037551. Dr. Ronald Petersen received personal compensation from Pfizer, Inc., Janssen Alzheimer's Immunotherapy. Merck, inc. Roche, Inc. Genentech, Inc. Biogen, Inc. Eli Lilly and Co. as a consultant or speaker.