量化脊髓MRI影像上孤立综合症:初步结果的前瞻性研究(P4.176)

文摘

目的:评估不同的脊髓(SC) mri定量措施radiologically-isolated综合症(RIS)对象与健康对照组(高碳钢)。背景:RIS描述无症状的个体出现的放射异常多发性硬化症(MS)的暗示。RIS科目经常发展随着时间的推移,女士的优化管理这些患者仍不清楚。定量SC-MRI措施,包括发表和magnetization-transfer-imaging派生指标已经证明了对潜在的显微结构的变化更加敏感,将这些技术应用于RIS可以提供洞察临床相关的病理生理的变化最早检测阶段的女士设计/方法:14 RIS主题和11高碳钢接受颈椎SC 3 t MRI及临床评价。感兴趣的限定同样被用来提取之间的轴向SC截面:SC-cross-sectional区域(CSA),分数各向异性(FA),意思是,垂直,平行扩散系数(医学博士,λ⊥,λ| |)和magnetization-transfer比(地铁)。手动分割的SC病变,SC-grey物质(通用汽车)和SC-white物质(WM)区域进行。学生的t和多变量线性回归评估SC-MRI措施RIS和高碳钢之间的差异。结果:RIS受试者低FA,λ| |和地铁与高碳钢(p < 0.05)。观察到的差异持续FA、MD和λ| |即使片和可见病变被排除在外(分别p = 0.11, 0.10, 0.02)。年龄,从性分析、RIS受试者低FA和地铁与高碳钢(p < 0.05)。 CONCLUSIONS: This pilot study is the first to demonstrate that a spectrum of quantitative SC-MRI measures appear to be different between RIS subjects and HCs. Although requiring prospective confirmation in larger studies, these findings suggest that microstructural changes consistent with inflammation, demyelination, and axonal injury are present in the SC of RIS, even in the absence of clinical symptoms and in otherwise normal-appearing tissue based on conventional MRI. Moreover, these findings suggest that quantitative SC-MRI may provide needed insight into disease mechanisms in the earliest identifiable stages of MS, and may have predictive value in the clinical management of RIS subjects.

披露:Jiwon博士没有披露。Alcaide-Leon博士已经收到了诺华的研究支持。Sankar博士没有披露。Cybulsky博士没有披露。安博士没有披露。博士他们没有披露。马丁没有披露。Hohol博士已经收到个人活动与拜耳医药保健有限公司的补偿、Idec, EMD Serono, Genzyme,诺华,罗氏作为议长和Teva神经科学,顾问,和/或顾问委员会成员。Selchen博士已经收到个人补偿活动Teva,默克公司Serono, Genzyme,诺华、Idec,百时美施贵宝,Boerhinger殷格翰集团。Bharatha博士没有披露。 Dr. O'Connor has received research support from Actelion, Bayer, Biogen Idec, BioMS, Cognosci, Daiichi Sankyo, EMD Serono, Genentech, Genmab, Novartis, Roche, Sanofi, and Teva.