rTMS与先进的PD On-Freezers。长期跟踪研究(S40.001)

文摘

目的:评估rTMS会话的长期疗效和安全性管理的“结冰”和出乎意料的偏移在先进的帕金森病(PD)。背景:冻结步态(雾)是一个独立的功能相关的帕金森病运动和认知障碍。治疗off-FOG相对简单,但在霜冻的难治性场景和它需要一个多学科小组的方法。设计/方法:一项随机,双盲,安慰剂对照研究包括43先进的PD患者获得12次rTMS超过4周(真实或虚假的)每三个月为一个9个月的时期。rTMS(20火车50刺激5赫兹)是在腿部运动区侧更影响方面紧随其后的是一个特定的康复计划(60分钟)。处理同步“准时”促进训练。所有患者日常日记来记录“准时”,“走开”,“瀑布”,“冻结发作”。主要疗效变量被雾Q (SF)、不可预测偏移和UPDRS(电机部分),次要结果准时和步态变量(抑扬顿挫,数量,步长和时间)。所有患者签署了书面同意。结果:冻结事件显著减少(p < 0.05)和雾Q (SF)显著提高(p < 0.001)在活动手臂。 Attacks of unpredicted offs also decreased significantly (p 0.03), whereas, the motor section of UPDRS improved, yet this was statistically non-significant. Number of falls reduced significantly (p<0.001) with improvement of turn time (p 0.04). Other gait variables were not affected. Long-term effects: the effects were maintained over the study period, the doses of dopaminergic drugs were individualized and modified according to the disease progression in both groups. No adverse events were recorded apart from mild transient headaches. Conclusions:rTMS has a positive effect in on-freezers with advanced PD with subsequent decrease of number of falls.

披露:谢哈塔博士没有披露。青年外交官访华团博士没有披露。El-Tamawy博士没有披露。Jaafary博士没有披露。