异常室周的梯度磁化传递率发生在多发性硬化症早期(S41.002)

文摘

背景:在建立多发性硬化症(MS)、白质(WM)磁化传递率(地铁)是最靠近心室异常,变得不那么有距离。现在还不知道如果发生这种情况女士从最早的临床阶段的目的:确定是否地铁梯度发生临床孤立后视神经炎(上)与临床的后续发展和探索协会明确女士(探测器)。方法:七十一人接受了核磁共振扫描4.6个月(平均)后(平均年龄33.5岁,49岁女性),和临床随访5年。37健康对照组(平均年龄34.4岁,25岁女性)也被扫描。在正常(NA) WM,地铁是评估在1毫米同轴乐队在侧脑室周围。前两个乐队包含脑脊液,所以被排除在外。地铁未来1-5mm梯度测量和5-10mm心室。结果:地铁是低NAWM乐队在组相比,控制。在控制,附近地铁值最高心室和减少距离;在组中,地铁是最低下的心室和增加在第一个5毫米,之前减少从5-10mm并联控制的价值观。 The MTR gradient over the first 5mm was significantly different between the ON and control groups (0.061 vs -0.033, p=0.010). The gradient was not affected by the presence of T2 lesions (p=0.989) or gadolinium-enhancing lesions (p=0.842). The MTR gradient of those in the ON group developing CDMS within two years was significantly steeper than those developing CDMS between 2-5 years (p=0.050), and those not developing CDMS during five-years follow-up (p=0.012). CONCLUSIONS: These results suggest that the processes underlying abnormal periventricular MTR gradients start early in the clinical course of MS, and may be relevant to the development of CDMS following ON.

披露:布朗医生没有披露。帕帝尼博士已经收到了诺华的研究支持。Brownlee博士没有披露。费尔南多博士没有披露。参孙博士没有披露。博士Nandini Wheeler-Kingshott没有披露。Ciccarelli博士已经与诺华收到个人补偿活动,生原体和通用电气作为顾问。米勒博士已经收到个人赔偿的活动与伦敦大学学院神经病学研究所和生原体Idec担任顾问。首页Dr.Declan甜菜已收到个人活动与补偿Ismar医疗公司,瑞士女士的社会,国际基金会和默克公司Serono座谈会。