11年的长期随访研究随机效益CIS审判

Study profile for the entire BENEFIT Study ^aIncludes one patient randomized to receive interferon beta-1b but treated with placebo. ^bIncludes one patient randomized to receive placebo but treated with interferon beta-1b. ^cIncludes one patient entered into the BENEFIT follow-up study after premature discontinuation of the BENEFIT Study. ^dFour lost to follow-up, 2 missing data, 1 noncompliance, 1 treatment failure, 2 refused final visit. ^eThree lost to follow-up, 1 relocated away from site, 1 pregnancy, 1 unable to attend visit because of job. ^fTo be eligible for the 11-year follow-up, patients only needed to be randomized and treated in the original BENEFIT Study (i.e., they did not need to be included in the previous BENEFIT analyses). BENEFIT = Betaferon/Betaseron in Newly Emerging MS for Initial Treatment; CDMS = clinically definite multiple sclerosis; DMT = disease-modifying therapy.