文摘
摘要目的:我们研究协会的认知功能与丘脑的体积,大叶性大脑皮层厚度、c[11]匹兹堡化合物b(加以)正电子发射断层扫描(PET)和白质(WM)作为一个潜在的髓鞘加以结合标记在女士的人口老龄化。
背景:先进的核磁共振成像技术用于成像髓不myelin-specific脑实质。相比之下,淀粉体示踪剂等加以最近显示目标髓;宠物可能候选人形象脱髓鞘疾病。
设计/方法:在以人群为基础的梅奥诊所的研究衰老,24女士4869参与者,与一个子集进行了大脑核磁共振(n = 16)和PiB-PET (n = 12)。一个女士轻度认知障碍患者完成标准而另一个痴呆和PiB-PET既不会满足标准。控制从同一队列是年龄,sex-matched女士(5:1)的病人。定量图像分析使用自动或半自动图像处理管道。
结果:医学患者认知记忆的z得分较低(p = 0.03)和语言比控制(p = 0.02)。MS患者小丘脑卷(p = 0.003),薄(p = 0.001)和颞皮层薄额叶皮层比控制(p = 0.045)。丘脑的体积损失与注意力执行性能下降(p = 0.02)。加以吸收减少区域的WM hyperintensities相比正常出现WM女士(p = 0.0002)和控制(p < 0.0001)。减少加以吸收区域的WM hyperintensities与视觉空间的性能下降(p = 0.02)。在全球皮质没有区别加以标准摄入值比率之间的女士和控制(p = 0.39)。
结论:丘脑的萎缩与低注意力执行函数年末女士,可能反映了丘脑-皮质WM损伤预测。PiB-PET作为一个潜在的WM损伤,与视觉空间的处理和可能反映了损伤协会区域连接。
研究支持:这项研究是由美国国立卫生研究院(P50 AG016574 R01 AG040042, U01 AG006786, C06 RR018898],明尼苏达合作生物技术和医学基因组学,埃尔希和马文Dekelboum家庭基金会和罗伯特·h·克拉丽斯史密斯和阿比盖尔范布伦阿尔茨海默病研究项目。
披露:Zeydan博士没有披露。劳博士收到个人活动与拜耳医药补偿作为顾问。Przybelski博士没有披露。施瓦兹博士没有披露。Tosakulwong博士没有披露。祖克博士没有披露。Senjem博士没有披露。甘特博士没有披露。罗伯茨博士没有披露。Mielke博士已经收到个人赔偿的活动与溶酶体疗法,inc .)担任顾问。 Dr. Mielke has received research support from Biogen. Dr. Benarroch has received personal compensation in an editorial capacity for being a section editor for Neurology. Dr. Rodriguez has received research support from Acorda Therapeutics, Inc. Dr. Machulda has nothing to disclose. Dr. Lesnick has nothing to disclose. Dr. Knopman has received personal compensation for activities with Lundbeck Pharmaceuticals.Dr. Knopman has received research support from Lilly Pharmaceuticals, Biogen and TauRX. Dr. Petersen received personal compensation for activities with Merck, Roche, Genentech, Biogen, and Eli Lilly and Co. Dr. Jack has received personal compensation for activities with Janssen Research & Development, LLC by providing consulting services. Dr. Jack has received research support from the National Institutes of Health (R01-AG011378, RO1-AG041851, RO1-AG037551. Dr. Katarci has received royalty payments from Takeda. Dr. Kantarci has nothing to disclose.
