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2018年9月04日 ;91 (10) 文章

利用语义入侵识别淀粉样蛋白轻度认知障碍的积极性

David a . Loewenstein,罗西·e·克里尔,史蒂文DeKosky,罗素·m·鲍尔,莫妮卡Rosselli,萨尔瓦多·m·Guinjoan,马列Adjouadi,Ailyn Penate,威廉·w·巴克,辛迪Goenaga,托德Golde,玛丽亚·t·Greig-Custo,凯文·s·汉森,春飞李,加布里埃尔Lizarraga,迈克尔Marsiske,野生动物这
第一次出版2018年8月3日, DOI: https://doi.org/10.1212/WNL.0000000000006128
David a . Loewenstein
从衰老中心(D.A.L.,R.E.C.) and Department of Psychiatry and Behavioral Sciences (D.A.L., R.E.C.), University of Miami Miller School of Medicine; Wien Center for Alzheimer's Disease and Memory Disorders (D.A.L., A.P., W.W.B., S.G., M.T.G.-C., R.D.), Mount Sinai Medical Center, Miami Beach; McKnight Brain Institute (S.D.), Department of Neurology (S.D., R.D.), Department of Clinical and Health Psychology (R.M.B.), Center for Translational Research in Neurodegenerative Diseases (T.G.), and Clinical and Translational Science Institute (K.S.H., M.M.), University of Florida, Gainesville; Department of Psychology (M.R.), Florida Atlantic University, Boca Raton; FLENI Foundation (S.M.G.), University of Buenos Aires Schools of Medicine and Psychology, Argentina; Department of Electrical and Computer Engineering (M.A., C.L., G.L.), College of Engineering and Computing, Florida International University Center for Advanced Technology and Education; and Herbert Wertheim College of Medicine (R.D.), Florida International University, Miami.
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罗西·e·克里尔
从衰老中心(D.A.L.,R.E.C.) and Department of Psychiatry and Behavioral Sciences (D.A.L., R.E.C.), University of Miami Miller School of Medicine; Wien Center for Alzheimer's Disease and Memory Disorders (D.A.L., A.P., W.W.B., S.G., M.T.G.-C., R.D.), Mount Sinai Medical Center, Miami Beach; McKnight Brain Institute (S.D.), Department of Neurology (S.D., R.D.), Department of Clinical and Health Psychology (R.M.B.), Center for Translational Research in Neurodegenerative Diseases (T.G.), and Clinical and Translational Science Institute (K.S.H., M.M.), University of Florida, Gainesville; Department of Psychology (M.R.), Florida Atlantic University, Boca Raton; FLENI Foundation (S.M.G.), University of Buenos Aires Schools of Medicine and Psychology, Argentina; Department of Electrical and Computer Engineering (M.A., C.L., G.L.), College of Engineering and Computing, Florida International University Center for Advanced Technology and Education; and Herbert Wertheim College of Medicine (R.D.), Florida International University, Miami.
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史蒂文DeKosky
从衰老中心(D.A.L.,R.E.C.) and Department of Psychiatry and Behavioral Sciences (D.A.L., R.E.C.), University of Miami Miller School of Medicine; Wien Center for Alzheimer's Disease and Memory Disorders (D.A.L., A.P., W.W.B., S.G., M.T.G.-C., R.D.), Mount Sinai Medical Center, Miami Beach; McKnight Brain Institute (S.D.), Department of Neurology (S.D., R.D.), Department of Clinical and Health Psychology (R.M.B.), Center for Translational Research in Neurodegenerative Diseases (T.G.), and Clinical and Translational Science Institute (K.S.H., M.M.), University of Florida, Gainesville; Department of Psychology (M.R.), Florida Atlantic University, Boca Raton; FLENI Foundation (S.M.G.), University of Buenos Aires Schools of Medicine and Psychology, Argentina; Department of Electrical and Computer Engineering (M.A., C.L., G.L.), College of Engineering and Computing, Florida International University Center for Advanced Technology and Education; and Herbert Wertheim College of Medicine (R.D.), Florida International University, Miami.
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罗素·m·鲍尔
从衰老中心(D.A.L.,R.E.C.) and Department of Psychiatry and Behavioral Sciences (D.A.L., R.E.C.), University of Miami Miller School of Medicine; Wien Center for Alzheimer's Disease and Memory Disorders (D.A.L., A.P., W.W.B., S.G., M.T.G.-C., R.D.), Mount Sinai Medical Center, Miami Beach; McKnight Brain Institute (S.D.), Department of Neurology (S.D., R.D.), Department of Clinical and Health Psychology (R.M.B.), Center for Translational Research in Neurodegenerative Diseases (T.G.), and Clinical and Translational Science Institute (K.S.H., M.M.), University of Florida, Gainesville; Department of Psychology (M.R.), Florida Atlantic University, Boca Raton; FLENI Foundation (S.M.G.), University of Buenos Aires Schools of Medicine and Psychology, Argentina; Department of Electrical and Computer Engineering (M.A., C.L., G.L.), College of Engineering and Computing, Florida International University Center for Advanced Technology and Education; and Herbert Wertheim College of Medicine (R.D.), Florida International University, Miami.
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莫妮卡Rosselli
从衰老中心(D.A.L.,R.E.C.) and Department of Psychiatry and Behavioral Sciences (D.A.L., R.E.C.), University of Miami Miller School of Medicine; Wien Center for Alzheimer's Disease and Memory Disorders (D.A.L., A.P., W.W.B., S.G., M.T.G.-C., R.D.), Mount Sinai Medical Center, Miami Beach; McKnight Brain Institute (S.D.), Department of Neurology (S.D., R.D.), Department of Clinical and Health Psychology (R.M.B.), Center for Translational Research in Neurodegenerative Diseases (T.G.), and Clinical and Translational Science Institute (K.S.H., M.M.), University of Florida, Gainesville; Department of Psychology (M.R.), Florida Atlantic University, Boca Raton; FLENI Foundation (S.M.G.), University of Buenos Aires Schools of Medicine and Psychology, Argentina; Department of Electrical and Computer Engineering (M.A., C.L., G.L.), College of Engineering and Computing, Florida International University Center for Advanced Technology and Education; and Herbert Wertheim College of Medicine (R.D.), Florida International University, Miami.
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萨尔瓦多·m·Guinjoan
从衰老中心(D.A.L.,R.E.C.) and Department of Psychiatry and Behavioral Sciences (D.A.L., R.E.C.), University of Miami Miller School of Medicine; Wien Center for Alzheimer's Disease and Memory Disorders (D.A.L., A.P., W.W.B., S.G., M.T.G.-C., R.D.), Mount Sinai Medical Center, Miami Beach; McKnight Brain Institute (S.D.), Department of Neurology (S.D., R.D.), Department of Clinical and Health Psychology (R.M.B.), Center for Translational Research in Neurodegenerative Diseases (T.G.), and Clinical and Translational Science Institute (K.S.H., M.M.), University of Florida, Gainesville; Department of Psychology (M.R.), Florida Atlantic University, Boca Raton; FLENI Foundation (S.M.G.), University of Buenos Aires Schools of Medicine and Psychology, Argentina; Department of Electrical and Computer Engineering (M.A., C.L., G.L.), College of Engineering and Computing, Florida International University Center for Advanced Technology and Education; and Herbert Wertheim College of Medicine (R.D.), Florida International University, Miami.
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马列Adjouadi
从衰老中心(D.A.L.,R.E.C.) and Department of Psychiatry and Behavioral Sciences (D.A.L., R.E.C.), University of Miami Miller School of Medicine; Wien Center for Alzheimer's Disease and Memory Disorders (D.A.L., A.P., W.W.B., S.G., M.T.G.-C., R.D.), Mount Sinai Medical Center, Miami Beach; McKnight Brain Institute (S.D.), Department of Neurology (S.D., R.D.), Department of Clinical and Health Psychology (R.M.B.), Center for Translational Research in Neurodegenerative Diseases (T.G.), and Clinical and Translational Science Institute (K.S.H., M.M.), University of Florida, Gainesville; Department of Psychology (M.R.), Florida Atlantic University, Boca Raton; FLENI Foundation (S.M.G.), University of Buenos Aires Schools of Medicine and Psychology, Argentina; Department of Electrical and Computer Engineering (M.A., C.L., G.L.), College of Engineering and Computing, Florida International University Center for Advanced Technology and Education; and Herbert Wertheim College of Medicine (R.D.), Florida International University, Miami.
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Ailyn Penate
从衰老中心(D.A.L.,R.E.C.) and Department of Psychiatry and Behavioral Sciences (D.A.L., R.E.C.), University of Miami Miller School of Medicine; Wien Center for Alzheimer's Disease and Memory Disorders (D.A.L., A.P., W.W.B., S.G., M.T.G.-C., R.D.), Mount Sinai Medical Center, Miami Beach; McKnight Brain Institute (S.D.), Department of Neurology (S.D., R.D.), Department of Clinical and Health Psychology (R.M.B.), Center for Translational Research in Neurodegenerative Diseases (T.G.), and Clinical and Translational Science Institute (K.S.H., M.M.), University of Florida, Gainesville; Department of Psychology (M.R.), Florida Atlantic University, Boca Raton; FLENI Foundation (S.M.G.), University of Buenos Aires Schools of Medicine and Psychology, Argentina; Department of Electrical and Computer Engineering (M.A., C.L., G.L.), College of Engineering and Computing, Florida International University Center for Advanced Technology and Education; and Herbert Wertheim College of Medicine (R.D.), Florida International University, Miami.
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威廉·w·巴克
从衰老中心(D.A.L.,R.E.C.) and Department of Psychiatry and Behavioral Sciences (D.A.L., R.E.C.), University of Miami Miller School of Medicine; Wien Center for Alzheimer's Disease and Memory Disorders (D.A.L., A.P., W.W.B., S.G., M.T.G.-C., R.D.), Mount Sinai Medical Center, Miami Beach; McKnight Brain Institute (S.D.), Department of Neurology (S.D., R.D.), Department of Clinical and Health Psychology (R.M.B.), Center for Translational Research in Neurodegenerative Diseases (T.G.), and Clinical and Translational Science Institute (K.S.H., M.M.), University of Florida, Gainesville; Department of Psychology (M.R.), Florida Atlantic University, Boca Raton; FLENI Foundation (S.M.G.), University of Buenos Aires Schools of Medicine and Psychology, Argentina; Department of Electrical and Computer Engineering (M.A., C.L., G.L.), College of Engineering and Computing, Florida International University Center for Advanced Technology and Education; and Herbert Wertheim College of Medicine (R.D.), Florida International University, Miami.
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辛迪Goenaga
从衰老中心(D.A.L.,R.E.C.) and Department of Psychiatry and Behavioral Sciences (D.A.L., R.E.C.), University of Miami Miller School of Medicine; Wien Center for Alzheimer's Disease and Memory Disorders (D.A.L., A.P., W.W.B., S.G., M.T.G.-C., R.D.), Mount Sinai Medical Center, Miami Beach; McKnight Brain Institute (S.D.), Department of Neurology (S.D., R.D.), Department of Clinical and Health Psychology (R.M.B.), Center for Translational Research in Neurodegenerative Diseases (T.G.), and Clinical and Translational Science Institute (K.S.H., M.M.), University of Florida, Gainesville; Department of Psychology (M.R.), Florida Atlantic University, Boca Raton; FLENI Foundation (S.M.G.), University of Buenos Aires Schools of Medicine and Psychology, Argentina; Department of Electrical and Computer Engineering (M.A., C.L., G.L.), College of Engineering and Computing, Florida International University Center for Advanced Technology and Education; and Herbert Wertheim College of Medicine (R.D.), Florida International University, Miami.
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托德Golde
从衰老中心(D.A.L.,R.E.C.) and Department of Psychiatry and Behavioral Sciences (D.A.L., R.E.C.), University of Miami Miller School of Medicine; Wien Center for Alzheimer's Disease and Memory Disorders (D.A.L., A.P., W.W.B., S.G., M.T.G.-C., R.D.), Mount Sinai Medical Center, Miami Beach; McKnight Brain Institute (S.D.), Department of Neurology (S.D., R.D.), Department of Clinical and Health Psychology (R.M.B.), Center for Translational Research in Neurodegenerative Diseases (T.G.), and Clinical and Translational Science Institute (K.S.H., M.M.), University of Florida, Gainesville; Department of Psychology (M.R.), Florida Atlantic University, Boca Raton; FLENI Foundation (S.M.G.), University of Buenos Aires Schools of Medicine and Psychology, Argentina; Department of Electrical and Computer Engineering (M.A., C.L., G.L.), College of Engineering and Computing, Florida International University Center for Advanced Technology and Education; and Herbert Wertheim College of Medicine (R.D.), Florida International University, Miami.
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玛丽亚·t·Greig-Custo
从衰老中心(D.A.L.,R.E.C.) and Department of Psychiatry and Behavioral Sciences (D.A.L., R.E.C.), University of Miami Miller School of Medicine; Wien Center for Alzheimer's Disease and Memory Disorders (D.A.L., A.P., W.W.B., S.G., M.T.G.-C., R.D.), Mount Sinai Medical Center, Miami Beach; McKnight Brain Institute (S.D.), Department of Neurology (S.D., R.D.), Department of Clinical and Health Psychology (R.M.B.), Center for Translational Research in Neurodegenerative Diseases (T.G.), and Clinical and Translational Science Institute (K.S.H., M.M.), University of Florida, Gainesville; Department of Psychology (M.R.), Florida Atlantic University, Boca Raton; FLENI Foundation (S.M.G.), University of Buenos Aires Schools of Medicine and Psychology, Argentina; Department of Electrical and Computer Engineering (M.A., C.L., G.L.), College of Engineering and Computing, Florida International University Center for Advanced Technology and Education; and Herbert Wertheim College of Medicine (R.D.), Florida International University, Miami.
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凯文·s·汉森
从衰老中心(D.A.L.,R.E.C.) and Department of Psychiatry and Behavioral Sciences (D.A.L., R.E.C.), University of Miami Miller School of Medicine; Wien Center for Alzheimer's Disease and Memory Disorders (D.A.L., A.P., W.W.B., S.G., M.T.G.-C., R.D.), Mount Sinai Medical Center, Miami Beach; McKnight Brain Institute (S.D.), Department of Neurology (S.D., R.D.), Department of Clinical and Health Psychology (R.M.B.), Center for Translational Research in Neurodegenerative Diseases (T.G.), and Clinical and Translational Science Institute (K.S.H., M.M.), University of Florida, Gainesville; Department of Psychology (M.R.), Florida Atlantic University, Boca Raton; FLENI Foundation (S.M.G.), University of Buenos Aires Schools of Medicine and Psychology, Argentina; Department of Electrical and Computer Engineering (M.A., C.L., G.L.), College of Engineering and Computing, Florida International University Center for Advanced Technology and Education; and Herbert Wertheim College of Medicine (R.D.), Florida International University, Miami.
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春飞李
从衰老中心(D.A.L.,R.E.C.) and Department of Psychiatry and Behavioral Sciences (D.A.L., R.E.C.), University of Miami Miller School of Medicine; Wien Center for Alzheimer's Disease and Memory Disorders (D.A.L., A.P., W.W.B., S.G., M.T.G.-C., R.D.), Mount Sinai Medical Center, Miami Beach; McKnight Brain Institute (S.D.), Department of Neurology (S.D., R.D.), Department of Clinical and Health Psychology (R.M.B.), Center for Translational Research in Neurodegenerative Diseases (T.G.), and Clinical and Translational Science Institute (K.S.H., M.M.), University of Florida, Gainesville; Department of Psychology (M.R.), Florida Atlantic University, Boca Raton; FLENI Foundation (S.M.G.), University of Buenos Aires Schools of Medicine and Psychology, Argentina; Department of Electrical and Computer Engineering (M.A., C.L., G.L.), College of Engineering and Computing, Florida International University Center for Advanced Technology and Education; and Herbert Wertheim College of Medicine (R.D.), Florida International University, Miami.
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加布里埃尔Lizarraga
从衰老中心(D.A.L.,R.E.C.) and Department of Psychiatry and Behavioral Sciences (D.A.L., R.E.C.), University of Miami Miller School of Medicine; Wien Center for Alzheimer's Disease and Memory Disorders (D.A.L., A.P., W.W.B., S.G., M.T.G.-C., R.D.), Mount Sinai Medical Center, Miami Beach; McKnight Brain Institute (S.D.), Department of Neurology (S.D., R.D.), Department of Clinical and Health Psychology (R.M.B.), Center for Translational Research in Neurodegenerative Diseases (T.G.), and Clinical and Translational Science Institute (K.S.H., M.M.), University of Florida, Gainesville; Department of Psychology (M.R.), Florida Atlantic University, Boca Raton; FLENI Foundation (S.M.G.), University of Buenos Aires Schools of Medicine and Psychology, Argentina; Department of Electrical and Computer Engineering (M.A., C.L., G.L.), College of Engineering and Computing, Florida International University Center for Advanced Technology and Education; and Herbert Wertheim College of Medicine (R.D.), Florida International University, Miami.
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迈克尔Marsiske
从衰老中心(D.A.L.,R.E.C.) and Department of Psychiatry and Behavioral Sciences (D.A.L., R.E.C.), University of Miami Miller School of Medicine; Wien Center for Alzheimer's Disease and Memory Disorders (D.A.L., A.P., W.W.B., S.G., M.T.G.-C., R.D.), Mount Sinai Medical Center, Miami Beach; McKnight Brain Institute (S.D.), Department of Neurology (S.D., R.D.), Department of Clinical and Health Psychology (R.M.B.), Center for Translational Research in Neurodegenerative Diseases (T.G.), and Clinical and Translational Science Institute (K.S.H., M.M.), University of Florida, Gainesville; Department of Psychology (M.R.), Florida Atlantic University, Boca Raton; FLENI Foundation (S.M.G.), University of Buenos Aires Schools of Medicine and Psychology, Argentina; Department of Electrical and Computer Engineering (M.A., C.L., G.L.), College of Engineering and Computing, Florida International University Center for Advanced Technology and Education; and Herbert Wertheim College of Medicine (R.D.), Florida International University, Miami.
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野生动物这
从衰老中心(D.A.L.,R.E.C.) and Department of Psychiatry and Behavioral Sciences (D.A.L., R.E.C.), University of Miami Miller School of Medicine; Wien Center for Alzheimer's Disease and Memory Disorders (D.A.L., A.P., W.W.B., S.G., M.T.G.-C., R.D.), Mount Sinai Medical Center, Miami Beach; McKnight Brain Institute (S.D.), Department of Neurology (S.D., R.D.), Department of Clinical and Health Psychology (R.M.B.), Center for Translational Research in Neurodegenerative Diseases (T.G.), and Clinical and Translational Science Institute (K.S.H., M.M.), University of Florida, Gainesville; Department of Psychology (M.R.), Florida Atlantic University, Boca Raton; FLENI Foundation (S.M.G.), University of Buenos Aires Schools of Medicine and Psychology, Argentina; Department of Electrical and Computer Engineering (M.A., C.L., G.L.), College of Engineering and Computing, Florida International University Center for Advanced Technology and Education; and Herbert Wertheim College of Medicine (R.D.), Florida International University, Miami.
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利用语义入侵识别淀粉样蛋白轻度认知障碍的积极性
大卫。Loewenstein,罗西E。亚洲区,史蒂文DeKosky,拉塞尔·M。鲍尔,莫妮卡Rosselli,萨尔瓦多·M。Guinjoan,马列Adjouadi,AilynPenate,威廉·W。巴克,辛迪Goenaga,托德Golde,玛丽亚·T。Greig-Custo,凯文·S。汉森,春飞李,盖伯瑞尔Lizarraga,迈克尔Marsiske,野生动物这
首页 2018年9月, 91年 (10) e976-e984; DOI:10.1212 / WNL.0000000000006128

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文摘

客观的语义入侵(SI)错误可能强调特定故障记忆临床前阿尔茨海默病(AD);然而,没有调查,以确定如果错误发生频率在遗忘轻度认知障碍的人(aMCI)确认为淀粉样蛋白阳性(艾米+)与那些有临床症状的aMCI-AD -淀粉样扫描(疑似non-AD病理学(SNAP))或人被诊断为其他大脑疾病影响认知。

方法aMCI接受八十八名参与者与大脑淀粉样PET和MRI扫描,并分为早期广告(艾米+),提前(艾米−),或其他神经/精神疾病诊断(艾米−)。我们专注于SI Loewenstein-Acevedo尺度为语义干扰和学习(LASSI-L)针对主动语义干扰(ψ;旧语义学习干扰新语义学习),失败后恢复PSI额外学习试验(frPSI)和追溯语义干扰(新语义学习干扰记忆老语义学习)。

结果SIs在PSI和frPSI区分艾米+广告,和其他non-AD病例。PSI和frPSI入侵证明适度高关联,减少体积内嗅皮层,颞区和supramarginal回。没有观察到这种联系的情况下提前。

结论SIs在LASSI-L PSI和frPSI独特的差异化艾米+和艾米−参与者aMCI可能反映了赤字和抑制和源记忆在临床前的广告不被传统认知措施。这可能代表一个特定的,非侵入性测试成功区分情况下与那些真正的广告。

术语表

广告=
阿尔茨海默病;
aMCI=
遗忘轻度认知障碍;
艾米+=
淀粉样蛋白阳性;
艾米−=
淀粉样蛋白-;
方差分析=
方差分析;
CDR=
临床痴呆评定;
CI=
置信区间;
第五版=
精神疾病诊断与统计手册第五版 ;
伦理委员会=
内嗅皮层;
罗斯福=
错误发现率;
frPSI=
未能从积极的语义干扰中恢复过来;
FTLD=
额颞叶大叶性变性;
HVLT-R=
霍普金斯言语学习Test-Revised;
LASSI-L=
Loewenstein-Acevedo尺度为语义干扰和学习;
MCI=
轻度认知障碍;
患者的=
细微精神状态检查;
ψ=
积极的语义干扰;
中华民国=
接收机算子的特点;
肢体重复性劳损症=
追溯语义干扰;
提前=
疑似non-Alzheimer病理学;
图基HSD测试=
图基诚实的显著差异测试

脚注

  • 去首页Neurology.org/N为充分披露。资金信息和披露认为作者相关的,如果有的话,年底提供这篇文章。

  • 收到了2018年2月17日。
  • 接受的最终形式2018年5月31日。
  • ©2018美国神经病学学会的首页
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