脑源性神经营养因子:生物-心理-社会关联轻度创伤性脑损伤和运动反应

恢复从轻度创伤性脑损伤(mTBI)是一个动态的、复杂的过程,临床前研究突出了脑源性神经营养因子(BDNF)作为一个重要的中介功能和病理生理的结果。尽管BDNF似乎也是人类复苏的一个重要因素,它的作用不太理解。我们的目的是(1)检查协会platelet-poor血浆浓度和血清脑源性神经营养因子的相关生物-心理-社会的结果(即mTBI复苏。,neurocognitive performance [attention, processing speed, memory, executive functioning], sleep, balance, mood, and self-reported symptoms) and (2) to assess BDNF response to a single-session of aerobic exercise (40 minutes of stationary cycling at 65%–75% maximum heart rate). There were 36 participants (ages 18–40; 19 male, 17 female) in 2 groups: (1) mTBI participants (n = 26) who were 14–25 days post-injury were randomized to either aerobic or non-aerobic exercise (low intensity stretching) and (2) demographically-matched, non-injured participants (n = 10) who participated in a single session of aerobic exercise. Results indicate that serum BDNF concentration has significant (p= 0.05),逆关系与睡眠障碍和焦虑状态。无显著关联运动类型和血清脑源性神经营养因子被发现,但有一个中小规模效应(= 0.08)增加有氧运动后血浆BDNF mTBI vs non-injured参与者。总的来说,外围BDNF浓度差相关,这表明了他们反映不同组织来源。血清脑源性神经营养因子选择生物-心理-社会状况更为敏感,尤其是睡眠质量与焦虑,不管损伤状态。另外,有氧运动可能发挥作用在增强platelet-poor mTBI后的急性期血浆脑源性神经营养因子响应。