文摘
摘要目的:描述眼跳行为跨多个神经退行性疾病,以确定的行为改变模式可能被用作针对疾病的生物标记物。
背景:动眼神经的电路和大脑区域的重叠影响眼球运动的神经退行性疾病建议评估可以区分和监控等疾病。眼跳典型化行为神经退行性疾病中发现的“指纹”,结合临床措施,可提高筛查、诊断和疾病进展的跟踪。
设计/方法:安大略神经退行性疾病研究计划收集的数据来自个人的六个神经退行性疾病:阿尔茨海默病(AD),轻度认知障碍(MCI)帕金森病(PD),肌萎缩性脊髓侧索硬化症(ALS),额颞叶痴呆(FTD)和血管性认知障碍(VCI)。病人(n = 520,年龄40 - 87)和一群健康的年龄组(n = 133,年龄50 - 93)完成了一项随机交叉pro和anti-saccade任务,而他们的眼球运动和高速视频跟踪。中央注视点的色彩传达的指令prosaccade(看看周边目标)或人群(不看周围的目标)。我们评估扫视参数包括任务错误,反应时间,以及他们与临床参数(例如MoCA得分)。
结果:异常模式在不同疾病组。每组任务相关的一个独特的子集参数显示异常——例如,人群的反应时间显著增加在PD和VCI相对于控制;人群方向错误(错误地看着周围目标)在非常短的延迟FTD和PD显著增加;和固定优惠(目光从固定的点)在广告和VCI显著增加。性能参数的一个子集(固定休息,人群方向错误)是控制之间的逐步恶化,MCI和广告。
结论:神经退行性疾病显示独特的眼球运动的“指纹”,提供洞察特定疾病的大脑功能障碍。这些指纹表示独特的行为对神经退化,生物标志物与临床相结合的措施,可以有力地通知新诊断工具和治疗方法。
披露:里克•博士没有披露。Coe博士没有披露。Brien博士没有披露。黑色博士已经收到个人赔偿咨询、担任科学顾问委员会说,或其他活动与霍夫曼罗氏。黑色博士收到Genentech研究支持,罗氏,生原体,通用电气医疗集团,狂热的/礼来. .Borrie博士已经收到了从生原体研究支持,默克,卫材,礼来,Abbvie,罗氏,基因泰克,诺华。Dowlatshahi博士没有披露。博士的手指已经收到了个人在一篇社论中补偿能力的实验:Clinical.Dr。弗里德曼没有披露。关颖珊博士没有披露。 Dr. Lang has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Consultant: AbbVie, Acorda, AFFiRis, Biogen, Janssen, Lilly, Lundbeck, Merck, Paladin, Roche, Seelos, Syneos, Sun Pharma, Theravance. Dr. Lang has received royalty, license fees, or contractual rights payments from Elsevier, Saunders, Wiley-Blackwell, Johns Hopkins Press, Cambridge University Press.Dr. Marras has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Grey Matter Technologies LLC, Acorda Therapeutics, EMD Serono. Dr. Marras has received research support from Acorda Therapeutics.Dr. Masellis has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Arkuda Therapeutics, Ionis Pharmaceuticals, and Alector Pharmaceuticals. Dr. Masellis has received research support from Roche, Novartis, Alector Pharmaceuticals.Dr. Shoesmith has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Mitsubishi Tanabe Pharma Canada. Dr. Swartz has nothing to disclose. Dr. Tan has nothing to disclose. Dr. Tartaglia has nothing to disclose. Dr. Zinman has received personal compensation for consulting, serving on a scientific advisory board, speaking, or other activities with Mitsubishi Tanabe Pharma Canada.Dr. Investigators has nothing to disclose. Dr. Munoz has nothing to disclose.
