文摘
摘要目的:确定微分EOAD NPS的轨迹和负载,在一群淀粉样蛋白阳性患者。
背景:认知能力的衰退速度越快,非典型形式的优势早发性老年痴呆症(EOAD)表明,神经精神症状(NPS)可能比在迟发性的广告更常见于EOAD(负载)。然而,之前的研究基于non-biomarker诊断军团显示不一致的结果。
设计/方法:115名参与者会议NIA-AA标准广告,使用淀粉pet,在记忆和衰老招募中心,加州大学旧金山分校。参与者被分为EOAD(发病的年龄≤65年;n = 69)或负载(> 65年;n = 46)。caregiver-reported神经精神库存-问卷(NPI-Q)评价和随访(年度互访,从1到8年)。NPI-Q意味着比较基线和回归模型调整临床痴呆评定(CDR)纵向进行确定EOAD /负载的影响诊断NPI-Q分数。互动与遗忘/ non-amnestic变体也被评估。
结果:没有EOAD和负载之间的区别性别(51 vs 59%),全球认知(MMSE 23.4±5和24.7±5)或功能性能(CDR总0.6±0.2 vs 0.6±0.3)。两组主要是遗忘的广告(EOAD 71%,负载80%)。在基线,NPI总分和某些子域分数(焦虑,易怒和夜间行为)高EOAD相比,负载(p< 0.05)。在NPI总纵,EOAD预测更高的分数(p< 0.01),夜间行为和运动障碍(p< 0.05)。比遗忘EOAD Non-amnestic EOAD显示更高的焦虑(p< 0.05)。
结论:NPS在EOAD更严重比负荷沿疾病,疾病的独立阶段(CDR)。某些领域如焦虑、易怒、夜间行为和运动障碍导致NPS的微分模式,建议有必要开发更多定制的治疗策略在EOAD解决这些临床表现。
披露:该处Falgas马丁内斯没有披露。该处Falgas马丁内斯没有披露。克莱默博士的机构已收到研究τ财团的支持。克莱默博士已经收到相关出版物的出版版税卫生保健。Rosen博士没有披露。米勒博士没有披露。Rabinovici博士已经收到个人薪酬在500 - 4999美元的范围为轴突神经科学作为顾问。Rabinovici博士已经收到个人薪酬在10000 - 49999美元的范围为卫材担任顾问。Rabinovici博士已经收到个人薪酬在500 - 4999美元的范围为通用电气医疗集团担任顾问。Rabinovici博士已经收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或为强生(Johnson & Joihnson数据安全监测委员会。 Dr. Rabinovici has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for JAMA Neurology. The institution of Dr. Rabinovici has received research support from NIH. The institution of Dr. Rabinovici has received research support from American College of Radiology. The institution of Dr. Rabinovici has received research support from Alzheimer’s Association. The institution of Dr. Rabinovici has received research support from Rainwater Charitable Foundation. The institution of Dr. Rabinovici has received research support from Avid Radiopharmaceuticals. Dr. Rabinovici has received personal compensation in the range of $5,000-$9,999 for serving as a Topic Chair, Course Director and teacher with AAN. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Grant reviewer with NIH. Lea Grinberg has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Curasen Inc. The institution of Lea Grinberg has received research support from NIH. The institution of Lea Grinberg has received research support from Eli Lilly. The institution of Lea Grinberg has received research support from BrightFouus. The institution of Lea Grinberg has received research support from Rainwater Charity Foundation. The institution of Thomas Neylan has received research support from National Institutes of Aging. Dr. Walsh has nothing to disclose.
