文摘
摘要目的:探讨精神疾病影响阿尔茨海默病(AD)。
背景:抑郁已经建立了一个风险因素在广告可能加快发展和疾病。少研究其他情绪障碍的影响,精神障碍和创伤后应激障碍(PTSD)的广告。
设计/方法:我们筛选公元1500年来自加州大学旧金山分校的患者记忆和衰老中心的历史精神障碍:抑郁、焦虑、双相情感障碍,精神分裂症和创伤后应激障碍。我们决定疾病患病率和调查与发病年龄(氧化铝),人口结构,典型的广告危险因素(高血压、高脂血症、糖尿病、教育和APOE4)以及小说AD-associated因素,之前详细(对于学习障碍,自身免疫性疾病,发作史)。
结果:43.3%(650/1500)有抑郁、焦虑32.3%(485/1500),1.2%(18/1500)双相情感障碍,1%的PTSD(15/1500), 0.4%(6/1500)精神分裂症。那些有抑郁或焦虑明显年轻的氧化铝(分别为2.1和3.0岁;p< 0.001)。进一步,降低阳极氧化铝一倍额外的精神病诊断:只有一个精神障碍的存在与一个年轻1.5岁广告的氧化铝,两个精神疾病导致了3.3年的历史减少阳极氧化铝,和三个或三个以上的诊断在氧化铝生产减少7.3年(p< 0.001)。抑郁和焦虑人群更多的女性,拥有更少数量的典型广告风险因素。抑郁组拥有更高的自身免疫性疾病(p= 0.01),而焦虑的人群拥有更大的发作频率(p= 0.002)。
结论:我们发现诊断与广告相关的抑郁和焦虑是反向的氧化铝。此外,氧化铝与越来越多的精神病学的诊断差异加剧,建议每个具有独特和添加剂对AD病理生理学的影响。我们推测,抑郁可能反映的存在更大的负担和焦虑的神经炎症更大程度的兴奋过度,鉴于对自身免疫性疾病和扣押。
披露:艾米丽Eijansantos没有披露。伊莎贝尔艾伦没有披露。负责博士接到NIH NIDCD研究支持。罗杰斯博士没有披露。莉婉Bogley没有披露。佩里收到博士研究的机构NIH / NIA的支持。Sturm博士没有披露。Rosen博士没有披露。Lea格林贝格已经收到个人薪酬在500 - 4999美元的范围作为顾问Curasen Inc . Lea格林贝格的机构收到NIH的研究支持。Lea格林贝格的机构收到礼来的研究支持。 The institution of Lea Grinberg has received research support from BrightFouus. The institution of Lea Grinberg has received research support from Rainwater Charity Foundation. Dr. Seeley has received personal compensation in the range of $500-$4,999 for serving as a Consultant for GLG Council. Dr. Seeley has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Guidepoint Global Consulting. Dr. Seeley has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Corcept Therapeutics. The institution of Dr. Seeley has received research support from NIH. The institution of Dr. Seeley has received research support from Rainwater Charitable Foundation. The institution of Dr. Seeley has received research support from Bluefield Project to Cure FTD. The institution of Dr. Seeley has received research support from Chan-Zuckerberg Initiative. Dr. Miller has nothing to disclose. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Axon Neurosciences. Dr. Rabinovici has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Eisai. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Consultant for GE Healthcare. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Johnson & Joihnson. Dr. Rabinovici has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for JAMA Neurology. The institution of Dr. Rabinovici has received research support from NIH. The institution of Dr. Rabinovici has received research support from American College of Radiology. The institution of Dr. Rabinovici has received research support from Alzheimer's Association. The institution of Dr. Rabinovici has received research support from Rainwater Charitable Foundation. The institution of Dr. Rabinovici has received research support from Avid Radiopharmaceuticals. Dr. Rabinovici has received personal compensation in the range of $5,000-$9,999 for serving as a Topic Chair, Course Director and teacher with AAN. Dr. Rabinovici has received personal compensation in the range of $500-$4,999 for serving as a Grant reviewer with NIH. The institution of Dr. Gorno Tempini has received research support from NIH. Dr. Miller has nothing to disclose.
