文摘
摘要目的:调查该地区协会剥夺指数(ADI),分配在人口普查块组级别,发展为痴呆的认知没有基线参与者(≥50岁)以人群为基础的梅奥诊所的研究衰老(MCSA)。
背景:数量有限的研究支持,社区不足可能导致认知障碍的风险,甚至独立于个体层面的社会经济措施和其他建立痴呆的危险因素。
设计/方法:ADI是小说,验证,综合衡量社区社会经济的缺点,使用17普查措施获取教育、就业、收入、贫困和住房特征;人口普查块组(即。,the closest approximation to a “neighborhood”) was the geographic unit of construction. ADI is publicly available (Neighborhood Atlas®, University of Wisconsin, School of Medicine and Public Health). Higher ADI scores indicate greater neighborhood socioeconomic deprivation. MCSA is an age/sex stratified random sample of Olmsted County (MN) residents. The study population consisted of 4,118 participants, with available ADI ranking values relative to the state for 2015 and at least one visit in 2008 – 2018. Cox proportional hazards models were fit to assess progression to dementia, adjusting for sex, education, and apolipoprotein E ɛ4 allele status, using age as the time scale.
结果:参与者的平均年龄(标准偏差(SD))为72.0(10.5)年,和49.5%是男性。293名参与者发展为痴呆在平均(SD)随访4.7(3.4)年。大多数生活在20%(比20%)socioeconomically弱势社区相对于国家与发展为痴呆的风险更高(HR = 1.56, 95%可信区间(1.031 - -2.365),p = 0.035)。
结论:人口普查块组级别社区劣势与发展为痴呆的风险增加有关,即使在一个资源充足的地区,如奥姆斯特德县、锰。需要持续的研究来了解潜在的关联路径,这将非常复杂。
披露:Vassilaki博士的机构已收到个人薪酬在500 - 4999美元的范围作为f .罗氏公司的顾问有限公司Vassilaki博士的机构收到NIH的研究支持。Vassilaki博士的机构收到生原体的研究支持。Vassilaki博士的机构已收到研究f .罗氏公司有限公司的支持。Vassilaki博士的机构已经收到了来自欧盟/研究支持布尔诺圣安妮的大学医院,捷克共和国。耶利米Aakre没有披露。安娜·卡斯蒂略没有披露。阿兰娜张伯伦的机构已经收到了来自美国国立卫生研究院的研究支持。威尔逊先生没有披露。沃尔特·克雷默的机构收到生原体的研究支持。Mielke博士已经收到个人薪酬在500 - 4999美元的范围为脑保护公司担任顾问。 Dr. Mielke has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. The institution of Dr. Geda has received research support from NIH. The institution of Dr. Machulda has received research support from NIH. Dr. Alhurani has nothing to disclose. Dr. Graff-Radford has received personal compensation for serving as an employee of Mayo Clinic. Dr. Graff-Radford has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Academy of Neurology. The institution of Dr. Graff-Radford has received research support from NIH. Dr. Vemuri has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Miller Medical Communications Inc.. The institution of Dr. Vemuri has received research support from NIH. Dr. Lowe has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for AVID Radiopharmaceutical. Dr. Lowe has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai Inc. The institution of Dr. Lowe has received research support from AVID Radiopharmaceuticals. The institution of Dr. Jack has received research support from NIH. The institution of Dr. Jack has received research support from Alexander Family Alzheimer's Disease Research Professorship of the Mayo Clinic. Dr. Knopman has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for DIAN TU study. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche, Inc.. Dr. Petersen has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen, Inc.. Dr. Petersen has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Eisai, Inc.. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck, Inc.. Dr. Petersen has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech, Inc.. Dr. Petersen has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche, Inc.. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has received publishing royalties from a publication relating to health care.
