文摘
摘要目的:比较利率和轨迹TDP-43-associated萎缩的大脑有或没有额颞叶大叶性变性(FTLD)和探索神经退化是否按照TDP-43形态学类型也不同。
背景:的主要病理衬底TDP-43 tau-negative FTLD,经常发现在老年人的大脑没有FTLD和神经退化的过程中是一个关键的球员。Non-FTLD TDP-43夹杂物不均匀,可分为两种形态:type-α和神经原纤维tangle-associated type-β。模式TDP-43-associated脑萎缩存在/缺乏FTLD或形态学亚型是未知的。
设计/方法:的纵向回顾研究295解剖2541例MRI扫描生成的十年中,我们使用了一个贝叶斯分层线性模型量化异同non-FTLD TDP-43 (type-α/ type-β)和FTLD-TDP (n = 68)在区域体积在不同时间点之前的死亡和折合成年率萎缩。因为阿尔茨海默病(AD)是一种频繁co-pathology non-FTLD TDP-43,我们进一步划分类型α/β基于存在缺乏intermediate-high可能性广告:AD-TDP type-β(n = 90), AD-TDPα型(n = 104)、和Pure-TDP (n = 31)。这项研究是由国家卫生研究院的基金:R01-AG037491-11 P30-AG062677, U01-AG006786, R35-AG11378 R01-AG041851。
结果:FTLD-TDP与海马萎缩率快,劣质颞(IT)和额叶皮质,与叶被该地区区分FTLD-TDP non-FTLD组。在额叶萎缩率调制了年龄年轻FTLD-TDP有最快的利率。在老FTLD-TDP患者中,海马和叶是神经退化的主要目标。Pure-TDP与最低利率和减少萎缩的大脑区域。
结论:有之间的差异和相似之处的纵向脑容量损失FTLD-TDP和non-FTLD TDP-43。内FTLD-TDP时代扮演了一个角色在受影响最严重的大脑区域。脑萎缩地区利率也随non-FTLD TDP-43类型。
披露:Buciuc博士没有披露。马丁先生没有披露。Nirubol Tosakulwonghas nothing to disclose. Dr. Murray has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Avid Radiopharmaceuticals. The institution of Dr. Murray has received research support from National Institute on Aging. The institution of Dr. Murray has received research support from Alzheimer's Association. The institution of Dr. Murray has received research support from Chan Zuckerberg Initiative. Matthew Senjem has received stock or an ownership interest from Align Technology, Inc.. Matthew Senjem has received stock or an ownership interest from Inovio Biomedical Corp.. Matthew Senjem has received stock or an ownership interest from Johnson & Johnson. Matthew Senjem has received stock or an ownership interest from Mesa Laboratories, Inc.. Matthew Senjem has received stock or an ownership interest from Nvidia Inc.. Matthew Senjem has received stock or an ownership interest from LHC Group, Inc.. Matthew Senjem has received stock or an ownership interest from Natus Medical Incorporated. Matthew Senjem has received stock or an ownership interest from Varex Imaging Corporation. Matthew Senjem has received personal compensation in the range of $100,000-$499,999 for serving as a IT Technical Specialist II with Mayo Clinic. Anthony Spychalla has nothing to disclose. Dr. Knopman has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for DIAN TU study. Dr. Boeve has received personal compensation in the range of $10,000-$49,999 for serving as an officer or member of the Board of Directors for Rainwater Charitable Foundation. The institution of Dr. Boeve has received research support from Biogen. The institution of Dr. Boeve has received research support from EIP Pharma. The institution of Dr. Boeve has received research support from Alector. The institution of Dr. Boeve has received research support from GE Healthcare. Dr. Boeve has received publishing royalties from a publication relating to health care. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Roche, Inc.. Dr. Petersen has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Biogen, Inc.. Dr. Petersen has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Eisai, Inc.. Dr. Petersen has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Merck, Inc.. Dr. Petersen has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Genentech, Inc.. Dr. Petersen has received personal compensation in the range of $10,000-$49,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche, Inc.. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Petersen has received publishing royalties from a publication relating to health care. Dr. Parisi has nothing to disclose. The institution of Ross Reichard has received research support from NIH. An immediate family member of Ross Reichard has received publishing royalties from a publication relating to health care. Dr. Dickson has nothing to disclose. The institution of Dr. Jack has received research support from NIH. The institution of Dr. Jack has received research support from Alexander Family Alzheimer's Disease Research Professorship of the Mayo Clinic. Dr. Whitwell has nothing to disclose. Dr. Josephs has nothing to disclose.
