文摘
摘要目的:评估的不同等离子体光神经丝(pNfL)放射检查孤立综合症患者(pwRIS)与健康对照组(高碳钢)和关联pNfL水平与先进的磁共振成像(MRI)在pwRIS标记。
背景:RIS女士是指那些没有典型的症状但大脑病变MRI特点与女士(pwm)。疾病修饰治疗的早期启动(DMT)可以提高pwm的预后,但目前没有明确如何管理pwRIS以证据为基础的指导方针。我们曾表明,绝大多数的pwRIS显示高比例的白质病变(wml)展示中央静脉(CVS)标志。之前的研究表明,血液NfL水平pwm与MRI的措施。我们假设pNfL水平增加一些pwRIS和与先进的核磁共振的措施。
设计/方法:14 RIS主题和6高碳钢接受3 t大脑和颈部脊髓磁共振成像和测量水平pNfL HD-1 Simoa平台(Quanterix)。学生的t;和Mann-Whitney U-tests被用来评估差异RIS和高碳钢。
结果:pwRIS pNfL与高碳钢的水平较高(p < 0.05)。pwRIS超过20 CVS-positive病变或超过50个总wml pNfL水平明显高于与高碳钢。
结论:试点研究是第一个证明pNfL pwRIS水平增加,与CVS-positive病变的数量和wml的总数。虽然在一个更大的群体要求未来的确认,这些发现表明,pNfL可能预后价值识别那些高危pwRIS发展前瞻性临床验证女士正在证实这个假说。
披露:施耐德博士已经收到个人薪酬在500 - 4999美元的范围为百时美施贵宝担任顾问。施耐德博士已经收到个人薪酬在500 - 4999美元的范围为诺华公司担任顾问。Brand-Arzamendi太太没有披露。蒂莫西·r·Lim没有披露。格莱斯特博士没有披露。梅勒妮Guenette没有披露。施耐德博士已经收到个人薪酬在500 - 4999美元的范围为百时美施贵宝担任顾问。施耐德博士已经收到个人薪酬在500 - 4999美元的范围为诺华公司担任顾问。哦收到博士个人薪酬在5000 - 9999美元的范围为罗氏公司担任顾问。博士的机构哦收到个人薪酬在5000 - 9999美元的范围为Biogen-Idec担任顾问。 Dr. Oh has received personal compensation in the range of $500-$4,999 for serving as a Consultant for BMS. Dr. Oh has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for EMD-Serono. Dr. Oh has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Sanofi-Genzyme. Dr. Oh has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Novartis. Dr. Oh has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Alexion. Dr. Oh has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. Dr. Oh has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen-Idec. Dr. Oh has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Sanofi-Genzyme. The institution of Dr. Oh has received research support from Biogen-Idec. The institution of Dr. Oh has received research support from EMD-Serono. The institution of Dr. Oh has received research support from Biogen-Idec.
