文摘
摘要目的:(i)来评估风险因素的影响(RFs)小血管疾病(计算)和偏头痛的百分比中央静脉标志(CVS) CVS + /−病变(% CVS + /−)检测到整个大脑和多发性硬化(MS)患者的条件;(2)调查是否球形意味着技术(SMT)可能区分CVS +从CVS−病变。
背景:并发症的影响在CVS % + /−女士调查诊断和监测一直不佳。
设计/方法:120 MS患者(女55%,名RRMS 70%),分层在4岁组(1组(18 - 30年),2组(31 - 45岁年),组3(46-56年),4组(57 - 77年),每组n = 30)执行大脑3 t-mri扫描协议包括3 depi-t2 *三和multishell扩散图像。CVS评估进行天赋*图像。广义估计方程(GEE)模型是用来比较SMT指标之间CVS +和CVS−病变。
结果:总共5303白质(WM)病变选择CVS评估(中位数:38病变/病人)。CVS + 3645 (68.7%)。病灶体积之间不同的CVS +和CVS−病变在整个大脑(中位数:1292毫米3vs 224毫米3分别;在大脑所有的4 p < 0.001)和条件(深/皮层下WM、室,juxtacortical infratentorial;(p < 0.001)。CVS中值% +从组1组下降4(从79.1%到57.7%)。深/皮层下WM的唯一次区域CVS +病变数量没有明显高于CVS−同行。年龄和偏头痛是CVS % +低的预测因子。CVS +显示SMT-EXTRAMD高(p = 0.001),高SMT-EXTRATRANS (p = 0.001)和低SMT-INTRA比CVS−病变(p = 0.02)。
结论:年龄是最强的预测% CVS +。CVS +病变的特点是更严重的炎症,脱髓鞘和纤维破坏。仔细评估并发症在CVS MS诊断和监测评估应该是强制性的,以避免误导解释和不恰当的治疗策略。
披露:Caterina Lapucci没有披露。弗朗西斯科·浅杯没有披露。Rebella小姐没有披露。Mavilio博士没有披露。Boffa先生没有披露。埃尔韦拉Sbragia没有披露。尼科洛Bruschi没有披露。伊丽莎白的形象没有披露。玛丽亚Cellerino没有披露。西蒙娜Schiavi没有披露。 Dr. Inglese has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for SANOFI GENZYME. Dr. Inglese has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for BIOGEN. Dr. Inglese has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for NOVARTIS. Dr. Inglese has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for MERCK-SERONO. Dr. Inglese has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for ROCHE. Dr. Inglese has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for MS Journal. The institution of Dr. Inglese has received research support from TEVA NEUROSCIENCE.
