文摘
摘要目的:评估载脂蛋白E(之间的关系APOE)ɛ4,横向和纵向的脑容量和τ负担在典型的阿尔茨海默病(AD),包括logopenic进行性失语(LPA)和后皮质萎缩(PCA)。
背景:APOEɛ4典型的广告是一个重要的遗传风险变体。而APOEɛ4影响脑容量和τ负担在典型的广告,是知之甚少的影响在神经影像学指标典型广告。
设计/方法:非典型广告(所有淀粉样看好宠物)的140名患者(82 LPA和58 PCA)被神经退行性研究小组招募了,接受了核磁共振和[18F] flortaucipir宠物。45岁患者纵向成像。区域灰质体积比率(SUVRs)和宠物标准吸收值计算和混合线性模型的影响评估APOEɛ4地区指标,校正了年龄、性别和颅内总额。
结果:在典型的广告(51%APOEɛ4运营商),APOEɛ4小航空公司4%基线海马卷(p = 0.04),趋势4%小杏仁核卷(p = 0.05),而非承运人。LPA,运营商同样趋势4%小杏仁核卷和非承运人(p = 0.09),尽管没有体积的差异观察之间的运营商和非承运人在PCA。没有观察到的差异的萎缩率非典型广告运营商和非承运人之间,LPA和主成分分析。tau-PET,海马体显示趋势基线τ吸收高6% (p = 0.08),但慢4%利率的τ积累(p = 0.04),在非典型广告运营商与非承运人。在主成分分析中,运营商τ积累在海马的几率高6% (p = 0.02)和非承运人。没有τ吸收的差异或利率APOE在LPA状态观察。
结论:APOEɛ4神经退化的影响模式和τ沉积在非典型广告通过促进内侧颞更多的参与,虽然APOE地位是与这些地区更快的恶化。
披露:辛格博士没有披露。Nirubol Tosakulwonghas nothing to disclose. Dr. Graff-Radford has received personal compensation for serving as an employee of Mayo Clinic. Dr. Graff-Radford has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for American Academy of Neurology. The institution of Dr. Graff-Radford has received research support from NIH. The institution of Dr. Machulda has received research support from NIH. Stephen Weigand has nothing to disclose. The institution of Dr. Taner has received research support from NIH. The institution of Christopher Schwarz has received research support from NIH. Matthew Senjem has received stock or an ownership interest from Align Technology, Inc.. Matthew Senjem has received stock or an ownership interest from Inovio Biomedical Corp.. Matthew Senjem has received stock or an ownership interest from Johnson & Johnson. Matthew Senjem has received stock or an ownership interest from Mesa Laboratories, Inc.. Matthew Senjem has received stock or an ownership interest from Nvidia Inc.. Matthew Senjem has received stock or an ownership interest from LHC Group, Inc.. Matthew Senjem has received stock or an ownership interest from Natus Medical Incorporated. Matthew Senjem has received stock or an ownership interest from Varex Imaging Corporation. Matthew Senjem has received personal compensation in the range of $100,000-$499,999 for serving as a IT Technical Specialist II with Mayo Clinic. The institution of Dr. Jack has received research support from NIH. The institution of Dr. Jack has received research support from Alexander Family Alzheimer's Disease Research Professorship of the Mayo Clinic. Dr. Lowe has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for AVID Radiopharmaceutical. Dr. Lowe has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai Inc. The institution of Dr. Lowe has received research support from AVID Radiopharmaceuticals. Dr. Josephs has nothing to disclose. Dr. Whitwell has nothing to disclose.
