文摘
摘要目的:τ病变之间的关系来确定负担和MRI体积损失和DTI白质束异常4-repeat tauopathies。
背景:进行性核上的麻痹(PSP)和corticobasal变性(CBD)显示4-repeatτ沉积在神经元(神经原纤维缠结和神经纤维网的线程),少突胶质细胞(蛇的身体)和星形胶质细胞(簇绒星形胶质细胞(PSP)或星形斑块(CBD))。确定MRI结果如何与潜在的病理关键评估他们的效用作为代理标记辅助诊断和临床试验的结果的措施。
设计/方法:47个患者临死前的3 t MRI包括体积和DTI扫描和后期病理诊断为PSP (n = 28)或CBD (n = 19)包括在内。在针对疾病的地区τ病变类型是半定量的分级。地区卷,分数各向异性(FA)和平均扩散系数(MD)相关使用线性回归模型与τ损伤分数单独考虑,根据细胞类型(神经元vs神经胶质),或者总结(τ)。
结果:大τ负担与总额在苍白球(p = 0.004),丘脑核(p < 0.001),黑质(p = 0.024),红核(p = 0.003)和中脑(p < 0.001),神经胶质病变(主要是盘体)驾驶的关联。神经病变趋势与体积的中央前皮层(p = 0.061)。FA降低,增加医学博士在上级小脑脚(SCP)与胶质τ小脑齿状(分别为p = 0.037, p = 0.019)和红核(p < 0.001)。在中脑,胶质病理学与增加MD (p = 0.008)。最后,增加皮层下白质MD与总τ优越的额(p = 0.020)和中央前皮质(p = 0.017)。
结论:MRI体积的关键皮层下和脑干区域,SCP变性和皮层下白质异常与τ沉积尸检病理学指标非常有益。此外,体积与胶质病变在皮层下和脑干区域,但趋势与神经病变在大脑皮层区域,可能暗示pathomechanisms不同。
披露:卡洛斯博士没有披露。Nirubol Tosakulwong没有披露。Stephen Weigand没有披露。Buciuc博士没有披露。阿里博士没有披露。希瑟·克拉克已收到个人赔偿作为梅奥诊所的一名雇员。希瑟·克拉克已收到个人补偿的范围为0 - 499美元作为一个编辑,副主编、编辑顾问委员会成员对美国演讲语言病理学杂志》上。希瑟·克拉克的机构收到NIH的研究支持。希瑟·克拉克已经收到相关出版物的出版版税卫生保健。博塔博士没有披露。 The institution of Joseph Duffy has received research support from NIH. Joseph Duffy has received publishing royalties from a publication relating to health care. Rene Utianski has nothing to disclose. The institution of Dr. Machulda has received research support from NIH. The institution of Christopher Schwarz has received research support from NIH. Robert I. Reid has received research support from Mayo Clinic Foundation. Matthew Senjem has received stock or an ownership interest from Align Technology, Inc.. Matthew Senjem has received stock or an ownership interest from Inovio Biomedical Corp.. Matthew Senjem has received stock or an ownership interest from Johnson & Johnson. Matthew Senjem has received stock or an ownership interest from Mesa Laboratories, Inc.. Matthew Senjem has received stock or an ownership interest from Nvidia Inc.. Matthew Senjem has received stock or an ownership interest from LHC Group, Inc.. Matthew Senjem has received stock or an ownership interest from Natus Medical Incorporated. Matthew Senjem has received stock or an ownership interest from Varex Imaging Corporation. Matthew Senjem has received personal compensation in the range of $100,000-$499,999 for serving as a IT Technical Specialist II with Mayo Clinic. The institution of Dr. Jack has received research support from NIH. The institution of Dr. Jack has received research support from Alexander Family Alzheimer's Disease Research Professorship of the Mayo Clinic. Dr. Ahlskog has received publishing royalties from a publication relating to health care. Dr. Dickson has nothing to disclose. Dr. Josephs has nothing to disclose. Dr. Whitwell has nothing to disclose.
