文摘
摘要目的:检查是否区域的白质hyperintensities模式(负责人)在不同logopenic进行性失语(LPA)和后皮质萎缩(PCA),以及研究负责人是否负担与认知或β-淀粉样蛋白的负担。
背景:研究负责人标志的小血管疾病和与年龄相关,认知能力下降,β-淀粉样蛋白沉积,阿尔茨海默病(AD)的风险更高。然而,人们很少知道白质高信号在频率和地区分布的非典型变异的广告,如LPA和PCA,或相关负责人是否认知或β-淀粉样蛋白负担这些症状。
设计/方法:七十五LPA和39 PCA招募的患者神经退行性研究小组和接受fluid-attenuated反转恢复MRI和匹兹堡化合物B(加以宠物。所有患者PiB-positive。室周的白质高信号与总量和区域分割和皮层下颅内总额调整的负担。调整负责人负担比较LPA和PCA和协会负责人和年龄之间的评估,全球标准加以吸收价值比率(SUVRs)和认知。
结果:总负责人负担没有组间差异。然而,PCA更大的右枕叶皮层下负责人负担,顶叶和颞叶与LPA相比。相反,LPA高等研究负责人负担了深的灰色和白色和更大的PCA相比,左顶叶皮层下负担。总负责人负担与年龄有关,与更大的负担与年龄较大的两组观察到但不相关的全球加以SUVR。更大的总负责人负担与visuoperceptual性能相关的校正前萎缩LPA队列,而这一趋势观察后修正。
结论:白质高信号不同区域的分布在非典型临床变异广告和与认知的结果。进一步的工作需要确定负责人在典型的广告反映了潜在的脑血管疾病或地区特定的神经退行性变化。
披露:芽庄(Pham星期四收到个人赔偿作为梅奥诊所的一名雇员。Graff-Radford博士已经收到个人赔偿作为梅奥诊所的一名雇员。Graff-Radford博士已经收到个人薪酬在5000 - 9999美元的范围作为一个编辑,副主编,或为美国神经病学学会编辑顾问委员会成员。首页Graff-Radford博士的机构收到NIH的研究支持。Machulda博士的机构收到NIH的研究支持。安东尼Spychalla没有披露。克里斯托弗·施瓦兹的机构收到NIH的研究支持。马修Senjem已收到股票或对齐技术的所有权,Inc . .马修Senjem已经收到Inovio生物医学公司股票或所有者权益. .马修Senjem已收到股票或强生公司的所有者权益。 Matthew Senjem has received stock or an ownership interest from Mesa Laboratories, Inc.. Matthew Senjem has received stock or an ownership interest from Nvidia Inc.. Matthew Senjem has received stock or an ownership interest from LHC Group, Inc.. Matthew Senjem has received stock or an ownership interest from Natus Medical Incorporated. Matthew Senjem has received stock or an ownership interest from Varex Imaging Corporation. Matthew Senjem has received personal compensation in the range of $100,000-$499,999 for serving as a IT Technical Specialist II with Mayo Clinic. Dr. Lowe has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for AVID Radiopharmaceutical. Dr. Lowe has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eisai Inc. The institution of Dr. Lowe has received research support from AVID Radiopharmaceuticals. The institution of Dr. Jack has received research support from NIH. The institution of Dr. Jack has received research support from Alexander Family Alzheimer's Disease Research Professorship of the Mayo Clinic. Dr. Josephs has nothing to disclose. Dr. Whitwell has nothing to disclose.
