文摘
摘要目的:铁积累与多系统萎缩患者的疾病严重程度
背景:豆状核的铁积累(LFN),黑质(SN)和齿状核(DN)在多系统萎缩(MSA)升高。在这项研究中,我们评估无创性铁积累在MSA,帕金森病(PD)和年龄匹配的健康对照组(HC),评价之间的关系铁沉积,在MSA临床症状的严重程度
设计/方法:所有参与者完成了神经系统检查和接受3 t大脑核磁共振。在MSA患者中,统一的多系统萎缩评定量表(UMSARS)和自然历史和神经保护在帕金森综合症(NNIPPS)等级量表应用。量化易感性地图(QSM)计算,磁化率值中位数LFN (interna globus螺旋体外,壳核),SN和DN获得铁浓度的措施。一般线性模型包括年龄作为协变量被用来组之间的比较结果,并评估的铁积累和临床评分之间的相关性疾病的严重程度(UMSARS和NNIPPS)。
结果:17 MSA(= 65±10岁;UMSARS = 36±15), 17 PD(年龄= 63±6;UPDRS-III() = 27±10)和17 HC参与者(年龄= 66±7)进行评估。PD相比,增加铁浓度在MSA患者指出LFN (p = 0.029)和DN (p = 0.022)。HC相比,MSA患者更大的铁浓度SN (p = 0.032)和DN (p = 0.002)。在MSA,大铁浓度SN和globus螺旋体答辩(GPe)与严重程度以UMSARS呈正相关(SN: R2= 0.46,p = 0.031;GPe: R2= 0.35,p = 0.021)和NNIPPS (SN: R2= 0.42,p = 0.071;GPe: R2= 0.34,p = 0.025)。
结论:先进的定量核磁共振方法演示了病态的铁积累在MSA患者相关临床病人的严重程度。这些数据支持使用QSM作为生物标志物MSA的疾病严重程度。
披露:Claassen博士已经收到个人薪酬在500 - 4999美元的范围作为顾问Lundbeck公司。它是一家Claassen博士已经收到个人薪酬在5000 - 9999美元的范围作为顾问Teva神经科学。Claassen博士已经收到个人薪酬在500 - 4999美元的范围作为顾问火花。Claassen博士已经收到个人薪酬在5000 - 9999美元的范围为在科学咨询服务或数据安全监测委员会Teva神经科学。Claassen博士已经收到个人薪酬在500 - 4999美元的范围为在科学咨询服务或数据安全监测委员会生命科学。Claassen博士已经收到个人薪酬在500 - 4999美元的范围作为一个编辑,副主编,或编辑顾问委员会成员对HD的见解。Claassen博士的机构收到NIH的研究支持。Claassen博士的机构已经接到CHDI研究支持。Claassen博士的机构已经接到HDSA研究支持。Claassen博士的机构已经收到了来自国防部的研究支持。 The institution of Dr. Claassen has received research support from Griffin Family Foundation. The institution of Dr. Claassen has received research support from Neurocrine. The institution of Dr. Claassen has received research support from Vaccinex. The institution of Dr. Claassen has received research support from AbbVie. The institution of Dr. Claassen has received research support from CHDI. The institution of Dr. Claassen has received research support from Genentech/ Roche. Paula Trujillo Diaz has nothing to disclose. Miss Iregui has nothing to disclose. Ms. Wynn has nothing to disclose. Dr. Hett has nothing to disclose. James Silverman has nothing to disclose. Dr. Yan has nothing to disclose. Dr. Kang has nothing to disclose. Dr. Stamler has received personal compensation for serving as an employee of Alterity Therapeutics.
