文摘
摘要目的:本研究调查了慢性COVID-19对大脑微观结构的影响。
背景:微观结构差异的比较中曾发现了COVID-19患者控制,尤其是脑岛楔片,不如时间和前扣带地区。
设计/方法:这里我们报告扩散磁共振成像(3 T西门子核磁共振)发现20个参与者(平均年龄:45.3,55%的女性),后立即恢复和3个月的后续行动。
分数各向异性(FA)、平均扩散系数(MD),扩散系数模式(MO),自由水比例(F),组织FA(脂肪)和组织MD(联合化疗)获得使用DTI数据与b = 700年和1400年(DIPY自由液模型)。区域的灰质和白质的兴趣使用FreeSurfer划定。评估基线和随访之间的差异,一个配对t检验,弗里德曼Wilcoxon测试和测试进行,纠正的错误发现率为0.05。效果(科恩的d)也计算(d > 0.45认为大效果)。
结果:这三个测试显示减少F在海马体和减少MD海马旁地区的后续的WM。在通用汽车,F在内侧眶地区增加。马里兰州的WM增加近中心地区和联合化疗是提高海马旁和外侧前额区域。
结论:这些结果表明,显微结构的异常后持续复苏。增加细胞外液(例如F和MD) COVID-19额叶建议传播的影响,同时减少F和MD在海马区域显示碎片积累作为炎症过程的一部分。没有影响的地区sub-acute COVID-19似乎在三个月内完全恢复。
披露:出纳员没有披露先生。乍得先生没有披露。Roudaia博士没有披露。博士Hashemi没有披露。Grosbein太太没有披露。基利波山Asaf没有披露。Goubran博士没有披露。程博士没有披露。黑色博士已经收到个人薪酬在5000 - 9999美元的范围为罗氏公司担任顾问。黑色博士已经收到个人薪酬在5000 - 9999美元的范围在生原体的演讲人。 The institution of Dr. Black has received research support from Hoffmann-La Roche. The institution of Dr. Black has received research support from Biogen. The institution of Dr. Black has received research support from GE Healthcare. The institution of Dr. Black has received research support from Lilly Avid. The institution of Dr. Black has received research support from Genentech. Chinthaka Heyn has received stock or an ownership interest from 11317423 CANADA LTD.. Chinthaka Heyn has received intellectual property interests from a discovery or technology relating to health care. Dr. Gao has nothing to disclose. Dr. Masellis has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Arkuda Therapeutics. Dr. Masellis has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Ionis. Dr. Masellis has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alector. Dr. Masellis has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Wave Life Sciences. The institution of Dr. Masellis has received research support from Canadian Institutes of Health Research. The institution of Dr. Masellis has received research support from Ontario Brain Institute. The institution of Dr. Masellis has received research support from Weston Brain Institute. The institution of Dr. Masellis has received research support from Washington University. The institution of Dr. Masellis has received research support from Alector. Dr. Masellis has received publishing royalties from a publication relating to health care. Dr. Rabin has nothing to disclose. Mr. Ji has nothing to disclose. The institution of Mr. Jegatheesan has received research support from Siemens Healthineers. Benjamin Lam has nothing to disclose. Bradley MacIntosh has nothing to disclose. Dr. Graham has received intellectual property interests from a discovery or technology relating to health care. Dr. Chen has nothing to disclose.
